Blundell J E, Leshem M B
J Pharm Pharmacol. 1975 Jan;27(1):31-7. doi: 10.1111/j.2042-7158.1975.tb09374.x.
5-Hydroxytryptophan (5-HTP), amphetamine and fenfluramine suppressed food intake in normal rats and in aminals with lesions of the lateral hypothalamus. The anorexic effect of amphetamine was reduced in lesioned animals compared with controls while the effect of 5-HTP like that of fenfluramine was increased. When administered in conjunction with anorexic drugs, 5-HTP markedly potentiated the anorexic effect of amphetamine in both control and lesioned animals. However, 5-HTP potentiated fenfluramine anorexia only in lesioned rats. These findings provide further evidence for the role of 5-hydroxytryptamine (5-HT,in the anorexic effect of fenfluramine, and suggest that a 5-HT mechanism, inhibitory for feeding, produces particulary severe suppression of food intake in rats with lateral hypothalamic lesions.
5-羟色氨酸（5-HTP）、苯丙胺和芬氟拉明可抑制正常大鼠以及下丘脑外侧受损动物的食物摄取。与对照组相比，苯丙胺对受损动物的厌食作用减弱，而5-HTP的作用如同芬氟拉明一样增强。当与厌食药物联合使用时，5-HTP可显著增强苯丙胺对对照组和受损动物的厌食作用。然而，5-HTP仅增强受损大鼠对芬氟拉明的厌食反应。这些发现为5-羟色胺（5-HT）在芬氟拉明厌食作用中的作用提供了进一步证据，并表明一种抑制进食的5-HT机制在患有下丘脑外侧损伤的大鼠中对食物摄取产生特别严重的抑制作用。
