下丘脑内注射后芬氟拉明和苯丙胺厌食作用的解离
Dissociation of the anorexic effects of fenfluramine and amphetamine following intrahypothalamic injection.
作者信息
Blundell J E, Leshem M B
出版信息
Br J Pharmacol. 1973 Jan;47(1):183-5. doi: 10.1111/j.1476-5381.1973.tb08174.x.
Abstract
Injections of amphetamine and fenfluramine directly into the hypothalamus produced changes in food intake dependent upon the site of injection. No significant modulation occurred following injections into the ventromedial nucleus. In the lateral hypothalamus both drugs gave rise to an overall depression of feeding behaviour but the time-course of action for the drugs differed and there was a high negative correlation between the action of the two drugs within individual animals. These findings provide further evidence for the belief that fenfluramine and amphetamine exert their anorexic actions through the lateral hypothalamus rather than the ventromedial nucleus, but suggest that different chemical mechanisms are involved in the anorexia produced by each drug.
摘要
直接向下丘脑注射苯丙胺和芬氟拉明会引起食物摄入量的变化，这种变化取决于注射部位。向腹内侧核注射后未发生明显的调节作用。在外侧下丘脑，两种药物均导致进食行为总体减少，但两种药物的作用时间进程不同，并且在个体动物中两种药物的作用之间存在高度负相关。这些发现为以下观点提供了进一步的证据，即芬氟拉明和苯丙胺通过外侧下丘脑而非腹内侧核发挥其厌食作用，但表明每种药物引起的厌食涉及不同的化学机制。
相似文献
1
Dissociation of the anorexic effects of fenfluramine and amphetamine following intrahypothalamic injection.下丘脑内注射后芬氟拉明和苯丙胺厌食作用的解离
Br J Pharmacol. 1973 Jan;47(1):183-5. doi: 10.1111/j.1476-5381.1973.tb08174.x.
2
Central action of anorexic agents: effects of amphetamine and fenfluramine in rats with lateral hypothalamic lesions.厌食药的中枢作用：苯丙胺和芬氟拉明对下丘脑外侧损伤大鼠的影响。
Eur J Pharmacol. 1974 Sep;28(1):81-8. doi: 10.1016/0014-2999(74)90115-0.
3
Possible mechanism for the effect of anorexic agents on feeding and hoarding behaviour in rats.厌食剂对大鼠进食和贮藏行为影响的可能机制。
Psychopharmacologia. 1971;22(3):224-9. doi: 10.1007/BF00401784.
4
The effect of 5-hydroxytryptophan on food intake and on the anorexic action of amphetamine and fenfluramine.5-羟色氨酸对食物摄入量以及对苯丙胺和芬氟拉明厌食作用的影响。
J Pharm Pharmacol. 1975 Jan;27(1):31-7. doi: 10.1111/j.2042-7158.1975.tb09374.x.
5
Differences between the anorexic actions of amphetamine and fenfluramine--possible effects on hunger and satiety.安非他命和芬氟拉明厌食作用的差异——对饥饿和饱腹感的可能影响。
J Pharm Pharmacol. 1976 Jun;28(6):471-7. doi: 10.1111/j.2042-7158.1976.tb02768.x.
6
[Comparative action of fenfluramine and amphetamine in rats with hypothalamic obesity].[氟苯丙胺和苯丙胺对下丘脑性肥胖大鼠的比较作用]
Rev Fr Etud Clin Biol. 1969 Oct;14(8):762-72.
7
Chronic anorexic and behavioural effects of the fenfluramine metabolite, norfenfluramine: an evaluation of its role in the actions of fenfluramine.芬氟拉明代谢产物去甲芬氟拉明的慢性厌食及行为效应：对其在芬氟拉明作用中所起作用的评估
Psychopharmacologia. 1974;38(1):67-74. doi: 10.1007/BF00421288.
8
Evidence for a difference in mechanism of action between fenfluramine- and amphetamine-induced anorexia.芬氟拉明和苯丙胺所致厌食症作用机制差异的证据。
J Pharm Pharmacol. 1973 Jan;25(1):49-54. doi: 10.1111/j.2042-7158.1973.tb09114.x.
9
Site of action of anorectic drugs: glucoprivic- versus food deprivation-induced feeding.食欲抑制药物的作用部位：糖缺乏与食物剥夺诱导的进食
Pharmacol Biochem Behav. 1987 Jun;27(2):291-7. doi: 10.1016/0091-3057(87)90572-7.
10
Comparison of the time course of the anorectic effect of fenfluramine and amphetamine with drug levels in blood.芬氟拉明和苯丙胺的食欲抑制作用时间进程与血液中药物水平的比较。
J Pharm Pharmacol. 1975 Mar;27(3):187-92. doi: 10.1111/j.2042-7158.1975.tb09435.x.
引用本文的文献
1
Different glial response to methamphetamine- and methylenedioxymethamphetamine-induced neurotoxicity.不同神经胶质细胞对甲基苯丙胺和亚甲基二氧甲基苯丙胺诱导的神经毒性的反应。
Naunyn Schmiedebergs Arch Pharmacol. 2003 May;367(5):490-9. doi: 10.1007/s00210-003-0747-y. Epub 2003 Apr 9.
2
Acute and chronic D-fenfluramine treatments have different effects on serotonin synthesis rates in the rat brain: an autoradiographic study.急性和慢性右旋芬氟拉明治疗对大鼠大脑中血清素合成速率有不同影响：一项放射自显影研究。
Neurochem Res. 1999 Dec;24(12):1611-20. doi: 10.1023/a:1021120603457.
3
Fenfluramine: a review of its pharmacological properties and therapeutic efficacy in obesity.芬氟拉明：对其药理特性及在肥胖症治疗中的疗效综述。
Drugs. 1975;10(4):241-323. doi: 10.2165/00003495-197510040-00001.
本文引用的文献
1
Amphetamine anorexia by direct action on the adrenergic feeding system of rat hypothalamus.苯丙胺通过直接作用于大鼠下丘脑的肾上腺素能摄食系统导致厌食。
Nature. 1968 Mar 2;217(5131):869-70. doi: 10.1038/217869a0.
2
Adrenergic stimulation of the rat diencephalon and its effect on food intake and hoarding activity.大鼠间脑的肾上腺素能刺激及其对食物摄取和贮藏活动的影响。
Q J Exp Psychol. 1970 May;22(2):125-32. doi: 10.1080/00335557043000050.
3
The role of brain norepinephrine in the anorexic effects of dextroamphetamine and monoamine oxidase inhibitors in the rat.脑去甲肾上腺素在右旋苯丙胺和单胺氧化酶抑制剂对大鼠的厌食作用中的角色。
Psychopharmacologia. 1971;22(2):151-61. doi: 10.1007/BF00403623.
4
Effect of fenfluramine on the electrical activity of the hypothalamic feeding centers.芬氟拉明对下丘脑进食中枢电活动的影响。
Physiol Behav. 1971 Sep;7(3):433-8. doi: 10.1016/0031-9384(71)90324-6.
5
[Comparative action of fenfluramine and amphetamine in rats with hypothalamic obesity].[氟苯丙胺和苯丙胺对下丘脑性肥胖大鼠的比较作用]
Rev Fr Etud Clin Biol. 1969 Oct;14(8):762-72.
6
Reciprocal hunger-regulating circuits involving alpha- and beta-adrenergic receptors located, respectively, in the ventromedial and lateral hypothalamus.相互作用的饥饿调节回路涉及分别位于下丘脑腹内侧和外侧的α-和β-肾上腺素能受体。
Proc Natl Acad Sci U S A. 1970 Oct;67(2):1063-70. doi: 10.1073/pnas.67.2.1063.
7
Is 5-hydroxytryptamine involved in the mechanism of action of fenfluramine?5-羟色胺是否参与芬氟拉明的作用机制？
J Pharm Pharmacol. 1971 Jun;23(6):468-70. doi: 10.1111/j.2042-7158.1971.tb08690.x.
8
Antagonism by methysergide of the 5-hydroxytryptamine-like action of toxic doses of fenfluramine in dogs.甲基麦角新碱对狗中毒剂量芬氟拉明的5-羟色胺样作用的拮抗作用。
J Pharm Pharmacol. 1970 Aug;22(8):637-8. doi: 10.1111/j.2042-7158.1970.tb10591.x.
Zotero 插件