Blundell J E, Leshem M B
Br J Pharmacol. 1973 Jan;47(1):183-5. doi: 10.1111/j.1476-5381.1973.tb08174.x.
Injections of amphetamine and fenfluramine directly into the hypothalamus produced changes in food intake dependent upon the site of injection. No significant modulation occurred following injections into the ventromedial nucleus. In the lateral hypothalamus both drugs gave rise to an overall depression of feeding behaviour but the time-course of action for the drugs differed and there was a high negative correlation between the action of the two drugs within individual animals. These findings provide further evidence for the belief that fenfluramine and amphetamine exert their anorexic actions through the lateral hypothalamus rather than the ventromedial nucleus, but suggest that different chemical mechanisms are involved in the anorexia produced by each drug.
直接向下丘脑注射苯丙胺和芬氟拉明会引起食物摄入量的变化，这种变化取决于注射部位。向腹内侧核注射后未发生明显的调节作用。在外侧下丘脑，两种药物均导致进食行为总体减少，但两种药物的作用时间进程不同，并且在个体动物中两种药物的作用之间存在高度负相关。这些发现为以下观点提供了进一步的证据，即芬氟拉明和苯丙胺通过外侧下丘脑而非腹内侧核发挥其厌食作用，但表明每种药物引起的厌食涉及不同的化学机制。
