苯丙胺的对羟基化在其外周作用模式中的作用。
The role of p-hydroxylation of amphetamine in its peripheral mode of action.
作者信息
Freeman J J, Sulser F
出版信息
J Pharm Pharmacol. 1975 Jan;27(1):38-42. doi: 10.1111/j.2042-7158.1975.tb09375.x.
Abstract
Desipramine completely abolished the blood pressure response to (+) amphetamine in the rat, whereas the tricyclic antidepressant iprindole did not reduce this response. Since both tricyclic drugs inhibit the aromatic hydroxylation of amphetamine, these studies do not support the hypothesis that hydroxylated metabolites of amphetamine, p-hydroxyamphetamine and p-hydroxynorephedrine are essential for the peripheral sympathomimetic effects of amphetamine.
摘要
地昔帕明完全消除了大鼠对（+）苯丙胺的血压反应，而三环类抗抑郁药茚满二酮并未降低这种反应。由于这两种三环类药物均抑制苯丙胺的芳香族羟基化作用，因此这些研究并不支持以下假说，即苯丙胺的羟基化代谢产物对羟基苯丙胺和对羟基去甲麻黄碱是苯丙胺外周拟交感神经作用所必需的。
Zotero 插件