Species variation with respect to the metabolism and excretion of d-amphetamine and d,l-N-hydroxyamphetamine succinate.

The metabolism of amphetamine and N-hydroxyamphetamine was studied in the rat and mouse. Extensive reduction of N-hydroxyamphetamine to amphetamine occurred in both species. In addition, para-hydroxylation of amphetamine was a common metabolic route, although it was more predominant in the rat. No appreciable difference in the 24-h excretion of amphetamine and p-hydroxyamphetamine in either species was seen after substitution of N-hydroxyamphetamine for amphetamine.