Danielson T J, Davis B A, Boulton A A
Can J Physiol Pharmacol. 1977 Jun;55(3):439-43. doi: 10.1139/y77-062.
The metabolism of amphetamine and N-hydroxyamphetamine was studied in the rat and mouse. Extensive reduction of N-hydroxyamphetamine to amphetamine occurred in both species. In addition, para-hydroxylation of amphetamine was a common metabolic route, although it was more predominant in the rat. No appreciable difference in the 24-h excretion of amphetamine and p-hydroxyamphetamine in either species was seen after substitution of N-hydroxyamphetamine for amphetamine.
在大鼠和小鼠中研究了苯丙胺和N-羟基苯丙胺的代谢。在这两个物种中，N-羟基苯丙胺均大量还原为苯丙胺。此外，苯丙胺的对羟基化是一条常见的代谢途径，尽管在大鼠中更为显著。用N-羟基苯丙胺替代苯丙胺后，在这两个物种中，苯丙胺和对羟基苯丙胺的24小时排泄量均未观察到明显差异。
