Pehek E A, Schechter M D
Department of Pharmacology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Pharmacol Biochem Behav. 1990 Jun;36(2):267-71. doi: 10.1016/0091-3057(90)90402-4.
The effects of the psychostimulant (+)cathine (norpseudoephedrine) were examined in a two-choice, food-motivated, drug-discrimination paradigm. Rats were able to discriminate cathine from vehicle and this effect was dose- and time-dependent. Prior administration of cathine resulted in a diminished response (tolerance) to subsequent cathine and this effect developed and dissipated rapidly. Thus, different dose-response curves were generated depending upon whether cathine or vehicle was administered the day before testing. The development of tolerance also shortened cathine's time course of action and enhanced the ability of haloperidol to antagonize the cathine cue. These results suggest caution in interpreting effects produced by intermittent drug injection schedules.
在一个双选、食物激励的药物辨别范式中，研究了精神兴奋剂（+）去甲伪麻黄碱（去甲麻黄碱）的作用。大鼠能够区分去甲伪麻黄碱和赋形剂，且这种作用具有剂量和时间依赖性。预先给予去甲伪麻黄碱会导致对随后给予的去甲伪麻黄碱反应减弱（耐受性），且这种作用迅速产生和消退。因此，根据测试前一天给予的是去甲伪麻黄碱还是赋形剂，会产生不同的剂量反应曲线。耐受性的产生还缩短了去甲伪麻黄碱的作用时间进程，并增强了氟哌啶醇拮抗去甲伪麻黄碱提示作用的能力。这些结果表明，在解释间歇性药物注射方案产生的效应时需谨慎。
