从巧茶中提取的两种胺类物质对大鼠的厌食作用。
Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats.
作者信息
Zelger J L, Carlini E A
出版信息
Pharmacol Biochem Behav. 1980 May;12(5):701-5. doi: 10.1016/0091-3057(80)90152-5.
The anorexigenic effects of cathine (phenylpropanolamine) and cathinone (alpha-aminopropiophenone), both amines obtained from Catha edulis Forsk. (Khat) were investigated by acute and chronic experiments in rats. Amphetamine was included for comparison purposes. Both khat amines reduced food intake when administered acutely and body weight when given chronically. Cathinone was more effective than cathine, and both were less active than amphetamine. Partial or total cross-tolerance was observed among the 3 drugs.
对从巧茶（Catha edulis Forsk.）中提取的两种胺类物质——去甲伪麻黄碱（苯丙醇胺）和卡西酮（α-氨基苯丙酮）的厌食作用，通过对大鼠进行急性和慢性实验进行了研究。为作比较，加入了苯丙胺。两种巧茶胺类物质在急性给药时均减少食物摄入量，慢性给药时均降低体重。卡西酮比去甲伪麻黄碱更有效，且二者均不如苯丙胺活性强。在这三种药物之间观察到了部分或完全交叉耐受性。
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