University of Cambridge, Department of Veterinary Medicine, Madingley Rd, Cambridge, Cambridgeshire, CB3 0ES, United Kingdom.
Virology. 2013 Jul 5;441(2):95-106. doi: 10.1016/j.virol.2013.03.014. Epub 2013 Apr 4.
Viral emergence as a result of zoonotic transmission constitutes a continuous public health threat. Emerging viruses such as SARS coronavirus, hantaviruses and henipaviruses have wildlife reservoirs. Characterising the viruses of candidate reservoir species in geographical hot spots for viral emergence is a sensible approach to develop tools to predict, prevent, or contain emergence events. Here, we explore the viruses of Eidolon helvum, an Old World fruit bat species widely distributed in Africa that lives in close proximity to humans. We identified a great abundance and diversity of novel herpes and papillomaviruses, described the isolation of a novel adenovirus, and detected, for the first time, sequences of a chiropteran poxvirus closely related with Molluscum contagiosum. In sum, E. helvum display a wide variety of mammalian viruses, some of them genetically similar to known human pathogens, highlighting the possibility of zoonotic transmission.
病毒通过动物源传播而出现是持续存在的公共卫生威胁。新型病毒如 SARS 冠状病毒、汉坦病毒和亨德拉病毒都有野生动物宿主。对病毒出现的地理热点地区的候选宿主物种的病毒进行特征描述是开发预测、预防或控制出现事件的工具的合理方法。在这里,我们探索了广泛分布在非洲的旧世界果蝠 Eidolon helvum 的病毒。我们发现了大量新型疱疹病毒和乳头瘤病毒,描述了一种新型腺病毒的分离,并首次检测到与传染性软疣病毒密切相关的蝙蝠痘病毒序列。总之,E. helvum 展示了多种哺乳动物病毒,其中一些在基因上与已知的人类病原体相似,突出了发生人畜共患传播的可能性。