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铜催化的苄醇和水合氨有氧氧化合成芳基腈。

Copper-catalyzed aerobic oxidative synthesis of aryl nitriles from benzylic alcohols and aqueous ammonia.

机构信息

School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, P R of China.

出版信息

Org Biomol Chem. 2013 May 28;11(20):3349-54. doi: 10.1039/c3ob00002h.

DOI:10.1039/c3ob00002h
PMID:23563148
Abstract

Copper-catalyzed direct conversion of benzylic alcohols to aryl nitriles was realized using NH3(aq.) as the nitrogen source, O2 as the oxidant and TEMPO as the co-catalyst. Furthermore, copper-catalyzed one-pot synthesis of primary aryl amides from alcohols was also achieved.

摘要

铜催化的苄醇直接转化为芳基腈，使用氨（水溶液）作为氮源，氧气作为氧化剂，TEMPO 作为共催化剂。此外，还实现了铜催化的醇一锅法合成伯芳基酰胺。

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