Department of Chemistry, National Taiwan Normal University, Taipei, Taiwan.
Org Biomol Chem. 2013 May 28;11(20):3393-9. doi: 10.1039/c3ob27352k.
Spirolactones, spirotetrahydrofurans, and spiropyrrolidines containing a vicinal cis-diol adjacent to the spiro-carbon center are prepared by one-pot epoxidation/spirocyclization of cyclohex-2-en-1-ols bearing an ester, alcohol, or amide functional side chain at the C(3) position of the ring.
含有紧邻螺碳中心的顺式二醇的螺内酯、螺四氢呋喃和螺吡咯烷，可通过在环的 C(3)位带有酯、醇或酰胺官能侧链的环己-2-烯-1-醇进行一锅法环氧化/螺环化反应来制备。
