• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

果蝇衰老和神经元衰退过程中转座元件的激活。

Activation of transposable elements during aging and neuronal decline in Drosophila.

机构信息

Cold Spring Harbor Laboratory, Cold Spring Harbor, New York, USA.

出版信息

Nat Neurosci. 2013 May;16(5):529-31. doi: 10.1038/nn.3368. Epub 2013 Apr 7.

DOI:10.1038/nn.3368
PMID:23563579
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3821974/
Abstract

We found that several transposable elements were highly active in Drosophila brain during normal aging. In addition, we found that mutations in Drosophila Argonaute 2 (Ago2) resulted in exacerbated transposon expression in the brain, progressive and age-dependent memory impairment, and shortened lifespan. These findings suggest that transposon activation may contribute to age-dependent loss of neuronal function.

摘要

我们发现，在正常衰老过程中，几种转座元件在果蝇大脑中高度活跃。此外，我们发现果蝇 Argonaute 2（Ago2）突变导致大脑中转座元件的表达加剧，表现为进行性和年龄依赖性记忆障碍以及寿命缩短。这些发现表明，转座元件的激活可能导致与年龄相关的神经元功能丧失。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/92879d72f92e/nihms451457f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/06642620a836/nihms451457f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/d63e03c7f4a4/nihms451457f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/92879d72f92e/nihms451457f3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/06642620a836/nihms451457f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/d63e03c7f4a4/nihms451457f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/bb31/3821974/92879d72f92e/nihms451457f3.jpg

相似文献

1
Activation of transposable elements during aging and neuronal decline in Drosophila.果蝇衰老和神经元衰退过程中转座元件的激活。
Nat Neurosci. 2013 May;16(5):529-31. doi: 10.1038/nn.3368. Epub 2013 Apr 7.
2
Somatic movement of the mariner transposable element and lifespan of Drosophila species.水手转座元件的体细胞移动与果蝇物种的寿命
Mutat Res. 1995 Oct;338(1-6):43-9. doi: 10.1016/0921-8734(95)00010-4.
3
Aging impairs intermediate-term behavioral memory by disrupting the dorsal paired medial neuron memory trace.衰老通过破坏背侧成对内侧神经元记忆痕迹来损害中期行为记忆。
Proc Natl Acad Sci U S A. 2012 Apr 17;109(16):6319-24. doi: 10.1073/pnas.1118126109. Epub 2012 Apr 2.
4
Distinctive neuronal networks and biochemical pathways for appetitive and aversive memory in Drosophila larvae.果蝇幼虫中用于食欲和厌恶记忆的独特神经网络及生化途径。
J Neurosci. 2009 Jan 21;29(3):852-62. doi: 10.1523/JNEUROSCI.1315-08.2009.
5
Interaction effect of mutations in the genes (piwi and aub) of the Argonaute family and hobo transposons on the integral survival parameters of Drosophila melanogaster.Argonaute 家族基因（piwi 和 aub）和 hobo 转座子突变对黑腹果蝇整体生存参数的互作效应。
Biogerontology. 2024 Feb;25(1):131-146. doi: 10.1007/s10522-023-10062-x. Epub 2023 Oct 21.
6
Aging specifically impairs amnesiac-dependent memory in Drosophila.衰老会特异性地损害果蝇中依赖遗忘的记忆。
Neuron. 2003 Dec 4;40(5):1003-11. doi: 10.1016/s0896-6273(03)00732-3.
7
A somatic piRNA pathway in the Drosophila fat body ensures metabolic homeostasis and normal lifespan.果蝇体脂肪组织中的体细胞 piRNA 通路可确保代谢平衡和正常寿命。
Nat Commun. 2016 Dec 21;7:13856. doi: 10.1038/ncomms13856.
8
P DNA element movement in somatic cells reduces lifespan in Drosophila melanogaster: evidence in support of the somatic mutation theory of aging.体细胞中P DNA元件的移动会缩短黑腹果蝇的寿命：支持衰老体细胞突变理论的证据。
Mutat Res. 1995 Oct;338(1-6):35-42. doi: 10.1016/0921-8734(95)00009-u.
9
Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.提高神经系统中自噬的基础水平可延长成年果蝇的寿命并增强其抗氧化能力。
Autophagy. 2008 Feb;4(2):176-84. doi: 10.4161/auto.5269. Epub 2007 Nov 6.
10
An Insulin-Sensitive Circular RNA that Regulates Lifespan in Drosophila.一种胰岛素敏感的环状 RNA，调控果蝇寿命。
Mol Cell. 2020 Jul 16;79(2):268-279.e5. doi: 10.1016/j.molcel.2020.06.011. Epub 2020 Jun 26.

引用本文的文献

1
A multi-omics analysis of human fibroblasts overexpressing an transposon reveals widespread disruptions in aging-associated pathways.对过表达转座子的人成纤维细胞进行的多组学分析揭示了衰老相关通路中广泛的破坏。
bioRxiv. 2025 Jul 17:2025.07.11.664466. doi: 10.1101/2025.07.11.664466.
2
Long-read detection of transposable element mobilization in the soma of hypomethylated Arabidopsis thaliana individuals.低甲基化拟南芥个体体细胞中转座元件动员的长读长检测
Genome Biol. 2025 Jul 30;26(1):231. doi: 10.1186/s13059-025-03691-7.
3
The dynamic genomes of Hydra and the anciently active repeat complement of animal chromosomes.

本文引用的文献

1
Transposable elements in TDP-43-mediated neurodegenerative disorders.TDP-43 介导的神经退行性疾病中的转座元件。
PLoS One. 2012;7(9):e44099. doi: 10.1371/journal.pone.0044099. Epub 2012 Sep 5.
2
Gamma neurons mediate dopaminergic input during aversive olfactory memory formation in Drosophila.在果蝇的厌恶嗅觉记忆形成过程中，γ神经元介导多巴胺能输入。
Curr Biol. 2012 Apr 10;22(7):608-14. doi: 10.1016/j.cub.2012.02.014. Epub 2012 Mar 15.
3
The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila.miR-34 调控果蝇衰老和神经退行性变。
水螅的动态基因组与动物染色体古老活跃的重复序列互补
Genome Biol. 2025 Jul 1;26(1):186. doi: 10.1186/s13059-025-03653-z.
4
Transposable element expression is associated with sex chromosome number in humans.转座元件的表达与人类性染色体数量相关。
PLoS Genet. 2025 Jun 26;21(6):e1011668. doi: 10.1371/journal.pgen.1011668. eCollection 2025 Jun.
5
An endogenous retroviral element co-opts an upstream regulatory sequence to achieve somatic expression and mobility.一种内源性逆转录病毒元件利用上游调控序列来实现体细胞表达和移动性。
Nucleic Acids Res. 2025 Jun 6;53(11). doi: 10.1093/nar/gkaf485.
6
Exploring the Relationship of Transposable Elements and Ageing: Causes and Consequences.探索转座元件与衰老的关系：原因与后果
Genome Biol Evol. 2025 May 30;17(6). doi: 10.1093/gbe/evaf088.
7
Reactivation of retrotransposable elements is associated with environmental stress and ageing.逆转录转座元件的重新激活与环境应激和衰老有关。
Nat Rev Genet. 2025 Apr 2. doi: 10.1038/s41576-025-00829-y.
8
Retrotransposon: an insight into neurological disorders from perspectives of neurodevelopment and aging.逆转录转座子：从神经发育和衰老角度洞察神经疾病
Transl Neurodegener. 2025 Mar 25;14(1):14. doi: 10.1186/s40035-025-00471-y.
9
The histone demethylase dLsd1 regulates organ size by silencing transposable elements.组蛋白去甲基化酶dLsd1通过沉默转座元件来调节器官大小。
Commun Biol. 2025 Feb 20;8(1):272. doi: 10.1038/s42003-025-07724-6.
10
MicroRNA biogenesis pathway alterations in aging.衰老过程中微小RNA生物合成途径的改变。
Extracell Vesicles Circ Nucl Acids. 2023 Aug 18;4(3):486-501. doi: 10.20517/evcna.2023.29. eCollection 2023.
Nature. 2012 Feb 15;482(7386):519-23. doi: 10.1038/nature10810.
4
Ataxia telangiectasia mutated (ATM) modulates long interspersed element-1 (L1) retrotransposition in human neural stem cells.共济失调毛细血管扩张突变基因 (ATM) 调节人类神经干细胞中的长散布元件-1 (L1) 反转录转座。
Proc Natl Acad Sci U S A. 2011 Dec 20;108(51):20382-7. doi: 10.1073/pnas.1100273108. Epub 2011 Dec 9.
5
Somatic retrotransposition alters the genetic landscape of the human brain.体细胞逆转座子改变了人类大脑的遗传景观。
Nature. 2011 Oct 30;479(7374):534-7. doi: 10.1038/nature10531.
6
Retrotransposon activation contributes to fragile X premutation rCGG-mediated neurodegeneration.反转录转座子的激活导致脆性 X 前突变 rCGG 介导的神经退行性变。
Hum Mol Genet. 2012 Jan 1;21(1):57-65. doi: 10.1093/hmg/ddr437. Epub 2011 Sep 22.
7
The endogenous siRNA pathway in Drosophila impacts stress resistance and lifespan by regulating metabolic homeostasis.果蝇内源性 siRNA 通路通过调节代谢稳态来影响应激抗性和寿命。
FEBS Lett. 2011 Oct 3;585(19):3079-85. doi: 10.1016/j.febslet.2011.08.034. Epub 2011 Aug 30.
8
DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration.DICER1 缺陷导致与年龄相关的黄斑变性中的 Alu RNA 毒性。
Nature. 2011 Mar 17;471(7338):325-30. doi: 10.1038/nature09830. Epub 2011 Feb 6.
9
Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis.鉴定肌萎缩性侧索硬化症患者神经元中人内源性逆转录病毒的活性位点。
Ann Neurol. 2011 Jan;69(1):141-51. doi: 10.1002/ana.22149.
10
Small RNA sorting: matchmaking for Argonautes.小 RNA 分拣：Argonautes 的匹配游戏。
Nat Rev Genet. 2011 Jan;12(1):19-31. doi: 10.1038/nrg2916. Epub 2010 Nov 30.