Ikutomi Masayasu, Yamasaki Masao, Matsusita Masashiro, Watari Yuji, Arashi Hiroyuki, Endo Goro, Yamaguchi Jun-ichi, Ohnishi Satoshi
NTT Medical Center, 5-9-22 Higashi-Gotanda, Shinagawa-ku, Tokyo, 141-8625, Japan,
Heart Vessels. 2014 Jan;29(1):119-22. doi: 10.1007/s00380-013-0345-y. Epub 2013 Apr 7.
We report the case of apical ballooning syndrome (ABS) in a female sibling. A 64-year-old woman was admitted to our hospital with sudden-onset chest pain. Cardiac enzymes were mildly elevated and an electrocardiogram showed broad ST-T changes. Emergency coronary angiography revealed no culprit lesion and left ventriculography demonstrated focal akinesis of the apical wall, which was consistent with ABS. Myocardial functional sympathetic innervations assessed using [(123)I]metaiodobenzylguanidine was severely impaired in the apical region. Her clinical symptoms and cardiac dysfunction recovered spontaneously. Just 1 year prior to our patient's cardiac event, her elder sister had the same symptoms and was also diagnosed with ABS. Both sisters were postmenopausal. The familial case of ABS is exceedingly rare, but these cases suggest a possible genetic etiology.
我们报告了一名女性同胞发生心尖球囊样综合征（ABS）的病例。一名64岁女性因突发胸痛入住我院。心肌酶轻度升高，心电图显示广泛的ST-T改变。急诊冠状动脉造影未发现罪犯病变，左心室造影显示心尖壁局部运动减弱，这与ABS相符。使用[（123）I]间碘苄胍评估的心尖区域心肌功能性交感神经支配严重受损。她的临床症状和心脏功能障碍自发恢复。就在我们的患者发生心脏事件的1年前，她的姐姐出现了相同的症状，也被诊断为ABS。姐妹俩均已绝经。ABS的家族性病例极为罕见，但这些病例提示可能存在遗传病因。
