在水中毒大鼠模型中使用颅内压波形分析评估脑顺应性

Assessment of brain compliance using ICP waveform analysis in water intoxication rat model.

作者信息

Oshio Kotaro, Onodera Hidetaka, Uchida Masashi, Tanaka Yuichiro, Hashimoto Takuo

机构信息

Department of Neurosurgery, St. Marianna University School of Medicine, Kanagawa, Japan.

出版信息

Acta Neurochir Suppl. 2013;118:219-21. doi: 10.1007/978-3-7091-1434-6_41.

DOI:10.1007/978-3-7091-1434-6_41

PMID:23564136

Abstract

Intracranial pressure (ICP) monitoring has been used widely for patients with intracranial hypertension. However, the data of mean ICP do not reflect various brain conditions correctly. Therefore, we performed ICP -waveform analysis to assess brain compliance. Data for ICP -waveform analysis were obtained by stereotactic intraventricle puncture. ICP waveform is expressed as a three-phase wave. Analyzed differential waveforms in a water intoxication model and continuous infusion models were evaluated respectively. In the water intoxication models, the second wave (P2) known to reflect compliance is elevated. ICP waveform analysis will be valuable for the assessment of the pathological condition of the brain.

摘要

颅内压（ICP）监测已广泛应用于颅内高压患者。然而，平均ICP数据并不能正确反映各种脑部状况。因此，我们进行了ICP波形分析以评估脑顺应性。通过立体定向脑室内穿刺获取ICP波形分析的数据。ICP波形表现为三相波。分别评估了水中毒模型和持续输注模型中的分析性微分波形。在水中毒模型中，已知反映顺应性的第二波（P2）升高。ICP波形分析对于评估脑部病理状况将具有重要价值。