Kozler P, Marešová D, Pokorný J
Institute of Physiology, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Physiol Res. 2017 Dec 30;66(Suppl 4):S511-S516. doi: 10.33549/physiolres.933797.
Continuous monitoring of the intracranial pressure (ICP) detects impending intracranial hypertension resulting from the impaired intracranial volume homeostasis, when expanding volume generates pressure increase. In this study, cellular brain edema (CE) was induced in rats by water intoxication (WI). Methylprednisolone (MP) was administered intraperitoneally (i.p.) before the start of CE induction, during the induction and after the induction. ICP was monitored for 60 min within 20 h after the completion of the CE induction by fibreoptic pressure transmitter. In rats with induced CE, ICP was increased (Mean+/-SEM: 14.25+/-2.12) as well as in rats with MP administration before the start of CE induction (10.55+/-1.27). In control rats without CE induction (4.62+/-0.24) as well as in rats with MP applied during CE induction (5.52+/-1.32) and in rats with MP applied after the end of CE induction (6.23+/-0.73) ICP was normal. In the last two groups of rats, though the CE was induced, intracranial volume homeostasis was not impaired, intracranial volume as well as ICP were not increased. It is possible to conclude that methylprednisolone significantly influenced intracranial homeostasis and thus also the ICP values in the model of cellular brain edema.
当颅内容量增加导致压力升高时，持续监测颅内压（ICP）可检测到因颅内容量稳态受损而即将出现的颅内高压。在本研究中，通过水 intoxication（WI）诱导大鼠发生细胞性脑水肿（CE）。在CE诱导开始前、诱导期间和诱导后腹腔内（i.p.）给予甲基强的松龙（MP）。在CE诱导完成后20小时内，通过光纤压力传感器监测ICP 60分钟。在诱导CE的大鼠中，ICP升高（平均值±标准误：14.25±2.12），在CE诱导开始前给予MP的大鼠中也是如此（10.55±1.27）。在未诱导CE的对照大鼠中（4.62±0.24），以及在CE诱导期间给予MP的大鼠中（5.52±1.32）和在CE诱导结束后给予MP的大鼠中（6.23±0.73），ICP均正常。在最后两组大鼠中，尽管诱导了CE，但颅内容量稳态未受损，颅内容量和ICP均未增加。可以得出结论，甲基强的松龙显著影响颅内稳态，从而也影响细胞性脑水肿模型中的ICP值。
