胰高血糖素样肽 1 可降低 1 型糖尿病患者由高血糖和低血糖引起的内皮功能障碍、炎症和氧化应激。
Glucagon-like peptide 1 reduces endothelial dysfunction, inflammation, and oxidative stress induced by both hyperglycemia and hypoglycemia in type 1 diabetes.
机构信息
Diabetes and Endocrinology, Insititut d'Investigacions Biomèdiques August Pi i Sunyer and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, Hospital Clínic Barcelona, Barcelona, Spain.
出版信息
Diabetes Care. 2013 Aug;36(8):2346-50. doi: 10.2337/dc12-2469. Epub 2013 Apr 5.
OBJECTIVE
Hyperglycemia and hypoglycemia currently are considered risk factors for cardiovascular disease in type 1 diabetes. Both acute hyperglycemia and hypoglycemia induce endothelial dysfunction and inflammation, raising the oxidative stress. Glucagon-like peptide 1 (GLP-1) has antioxidant properties, and evidence suggests that it protects endothelial function.
RESEARCH DESIGN AND METHODS
The effect of both acute hyperglycemia and acute hypoglycemia in type 1 diabetes, with or without the simultaneous infusion of GLP-1, on oxidative stress (plasma nitrotyrosine and plasma 8-iso prostaglandin F2alpha), inflammation (soluble intercellular adhesion molecule-1 and interleukin-6), and endothelial dysfunction has been evaluated.
RESULTS
Both hyperglycemia and hypoglycemia acutely induced oxidative stress, inflammation, and endothelial dysfunction. GLP-1 significantly counterbalanced these effects.
CONCLUSIONS
These results suggest a protective effect of GLP-1 during both hypoglycemia and hyperglycemia in type 1 diabetes.
目的
目前认为 1 型糖尿病的高血糖和低血糖是心血管疾病的危险因素。急性高血糖和低血糖均可导致内皮功能障碍和炎症，增加氧化应激。胰高血糖素样肽 1（GLP-1）具有抗氧化特性，有证据表明它能保护内皮功能。
研究设计和方法
本研究评估了 1 型糖尿病患者在急性高血糖和急性低血糖时，有无同时输注 GLP-1，对氧化应激（血浆硝基酪氨酸和血浆 8-异前列腺素 F2alpha）、炎症（可溶性细胞间黏附分子-1 和白细胞介素-6）和内皮功能障碍的影响。
结果
高血糖和低血糖均能急性诱导氧化应激、炎症和内皮功能障碍，GLP-1 能显著拮抗这些作用。
结论
这些结果提示 GLP-1 在 1 型糖尿病的低血糖和高血糖期间具有保护作用。
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