Davis T R, Holloway I T, Pooley J
Department of Orthopaedics, University of Newcastle-upon-Tyne, Royal Victoria Infirmary, Great Britain.
Undersea Biomed Res. 1990 May;17(3):201-11.
As the pathogenesis of dysbaric osteonecrosis is not fully understood, we investigated the effects of compressed air, decompression, and elevated oxygen levels on bone blood flow. Bone blood flow was measured in 4 groups of rabbits using the radioactive-labeled microsphere technique. In the Control and Oxygen groups it was measured at normal pressure (1 ATA) at the end of 4-h exposures to air and 100% oxygen, respectively. In the Pressure group it was measured "at pressure" at the end of a 4-h exposure to compressed air (3 ATA) and in the Decompression group it was measured after decompression following a 3.5-h exposure to compressed air (3 ATA). Femoral head blood flow was significantly lower (P = 0.027) in both the Pressure (7.5 ml.100 g-1.min-1) and Decompression (7.1 ml.100 g-1.min-1) groups than in the Control group (13.0 ml.100 g-1.min-1). Moreover, the distribution of blood flow between the cortex and marrow of the humerus differed significantly (P = 0.044) between the Control and Pressure groups. No differences were found between the bone blood flow rates of the Control and Oxygen groups. It is concluded that femoral head blood flow is reduced by prolonged exposure to compressed air (without decompression) and that this is not solely an effect of the high partial pressure of oxygen.
由于减压性骨坏死的发病机制尚未完全明确，我们研究了压缩空气、减压及氧分压升高对骨血流的影响。采用放射性标记微球技术，对4组家兔的骨血流进行了测量。在对照组和氧组中，分别于4小时空气暴露和100%氧气暴露结束时，在常压（1个绝对大气压）下测量骨血流。在压力组中，于4小时压缩空气（3个绝对大气压）暴露结束时“在压力下”测量骨血流；在减压组中，于3.5小时压缩空气（3个绝对大气压）暴露后的减压过程结束后测量骨血流。压力组（7.5 ml·100 g-1·min-1）和减压组（7.1 ml·100 g-1·min-1）的股骨头血流均显著低于对照组（13.0 ml·100 g-1·min-1）（P = 0.027）。此外，对照组和压力组之间肱骨皮质和骨髓的血流分布存在显著差异（P = 0.044）。对照组和氧组的骨血流速率未发现差异。研究得出结论，长时间暴露于压缩空气（未减压）会导致股骨头血流减少，且这并非仅仅是高氧分压的作用。
