Pak C Y, Ohata M, Holt K
Kidney Int. 1975 Mar;7(3):154-60. doi: 10.1038/ki.1975.23.
Reliable techniques for the calculation of activity product (state of saturation), formation product (limit of metastability) and crystal growth of calcium oxalate were devised. The activity product at saturation was 2.53 times 10 minus 9 M2, and was independent of duration of incubation, solid-to-solution ratio, pH, calcium concentration or ionic strength. These tehcniques were utilized to assess the effect of disodium ethane-1-hydroxy-1, 1-diphosphonate (EHDP) on crystallization of calcium oxalate in an aqueous salt solution in vitro. EHDP increased the formation product of calcium oxalate, indicating an inhibition of nucleation of calcium oxalate. Further, it inhibited the crystal growth of calcium oxalate.
已设计出可靠的技术来计算草酸钙的活度积（饱和状态）、生成积（亚稳极限）和晶体生长。饱和时的活度积为2.53×10⁻⁹ M²，且与孵育时间、固液比、pH值、钙浓度或离子强度无关。这些技术被用于评估1-羟基-1,1-二膦酸二钠（EHDP）对体外盐水溶液中草酸钙结晶的影响。EHDP增加了草酸钙的生成积，表明对草酸钙的成核有抑制作用。此外，它还抑制了草酸钙的晶体生长。
