Francis M D, Slough C L, Briner W W, Oertel R P
Calcif Tissue Res. 1977 May 31;23(1):53-60. doi: 10.1007/BF02012766.
Comparisons of mellitate (MA) and ethane-1-hydroxy-1,1-diphosphonate (EHDP) have been carried out in studies of enamel etching, calcium phosphate crystal growth and animal calculus deposition. In enamel etch studies at pH 5, 6, or 7 and after treatment times of 5 or 170 min, EHDP was less damaging to enamel surfaces than MA as determined by scanning electron microscopy, grazing angle electron diffraction, and quantitative etch solution analyses. Both MA and EHDP inhibited hydroxyapatite crystal growth, although EHDP was more effective than MA. The formation of a tricalcium mellitate surface phase is suggested as the basis of the MA crystal growth effect on apatite. Both MA and EHDP also inhibited rat calculus formation, but EHDP was more effective than MA. The relation between crystal growth inhibition, surface phase solubility, and anti-calculus activity is discussed and a generalized principal for determining an effective inhibitor of calculus is suggested.
在牙釉质蚀刻、磷酸钙晶体生长和动物牙结石沉积研究中，已对 mellitate（MA）和乙烷 -1-羟基 -1,1-二膦酸盐（EHDP）进行了比较。在 pH 值为 5、6 或 7 且处理时间为 5 分钟或 170 分钟的牙釉质蚀刻研究中，通过扫描电子显微镜、掠角电子衍射和蚀刻溶液定量分析确定，EHDP 对牙釉质表面的损害小于 MA。MA 和 EHDP 均抑制羟基磷灰石晶体生长，尽管 EHDP 比 MA 更有效。有人提出形成 mellitate 三钙表面相是 MA 对磷灰石晶体生长产生影响的基础。MA 和 EHDP 也均抑制大鼠牙结石形成，但 EHDP 比 MA 更有效。讨论了晶体生长抑制、表面相溶解度和抗牙结石活性之间的关系，并提出了确定有效牙结石抑制剂的一般原则。
