Akca Ozan, Bautista Alexander
Crit Care. 2013 Apr 8;17(2):129. doi: 10.1186/cc12563.
In the previous issue of Critical Care, Jung and colleagues report on the preventive effects of hypercapnia on ventilator-induced diaphragmatic dysfunction (VIDD) under controlled ventilation. Possibly, a combination of controlled hypercapnia and allowed spontaneous breathing efforts may provide complementary protection for diaphragm and respiratory functionality during mechanical ventilation. However, further safety and efficacy studies need to be performed in various different animal models and patients before a universal application of hypercapnia in the critical care setting for the prevention of VIDD can be considered.
在上一期的《重症监护》杂志中，荣格及其同事报告了在控制通气条件下高碳酸血症对呼吸机诱发膈肌功能障碍（VIDD）的预防作用。或许，控制性高碳酸血症与允许自主呼吸努力相结合，可能会在机械通气期间为膈肌和呼吸功能提供互补性保护。然而，在考虑将高碳酸血症普遍应用于重症监护环境以预防VIDD之前，需要在各种不同的动物模型和患者中进行进一步的安全性和有效性研究。
