Caldefie-Chézet Florence, Dubois Virginie, Delort Laetitia, Rossary Adrien, Vasson Marie-Paule
Clermont université, université d'Auvergne, UFR pharmacie, 28, place Henri-Dunant, 63000 Clermont-Ferrand, France.
Ann Endocrinol (Paris). 2013 May;74(2):90-101. doi: 10.1016/j.ando.2013.03.005. Epub 2013 Apr 6.
More than one million new cases of breast cancer are diagnosed each year worldwide and more than 400,000 deaths occur due to this pathology. Obesity is a risk factor for postmenopausal breast cancer and the place held by the adipose tissue and secretions (i.e. adipokines) begins to be recognized. Indeed, firstly, plasma adipokine levels, modulated in obesity situation, could have effects "remotely" on mammary carcinogenesis and, secondly, breast cancer cells are surrounded by adipocyte microenvironment, which is probably more important in the case of obesity, and may be locally influenced by it. In this context, leptin appears to be strongly involved in mammary carcinogenesis and may contribute to the angiogenesis process and local pro-inflammatory mechanisms, especially in obese patients for whom increased metastatic potential and risk of mortality are described.
全球每年有超过100万例新发乳腺癌病例被诊断出来，并且有超过40万例死亡归因于这种疾病。肥胖是绝经后乳腺癌的一个风险因素，脂肪组织及其分泌物（即脂肪因子）所起的作用开始得到认可。事实上，首先，在肥胖情况下受到调节的血浆脂肪因子水平可能会对乳腺癌发生产生“远程”影响；其次，乳腺癌细胞被脂肪细胞微环境所包围，在肥胖情况下这可能更为重要，并且可能受到其局部影响。在这种背景下，瘦素似乎在乳腺癌发生中起着重要作用，并且可能有助于血管生成过程和局部促炎机制，特别是在那些被描述为具有更高转移潜能和死亡风险的肥胖患者中。
