Zhou Guangxin, Shi Xin, Zhang Junfeng, Wu Sujia, Zhao Jianning
Department of Orthopaedics, Jinling Hospital, Nanjing, Jiangsu, China.
J Int Med Res. 2013 Feb;41(1):1-12. doi: 10.1177/0300060513475959. Epub 2013 Jan 24.
Osteosarcoma is a primary malignant bone tumour with high morbidity that occurs mainly in children and adolescents. While the molecular basis of osteosarcoma has received considerable attention, the cellular and molecular mechanisms underlying pre- and postoperative metastasis formation and the development of chemoresistance remain unclear. MicroRNAs (miRNAs), a class of 22-nucleotide noncoding RNAs, have emerged as critical components of gene-regulatory networks controlling numerous important pathophysiological processes, including the initiation and progression of cancers. Studies on miRNAs have opened new avenues for both the diagnosis and treatment of cancer. This review discusses the roles of miRNAs in osteosarcoma and their potential applications for the diagnosis, prognosis and treatment of this malignancy. As a rapidly evolving field of basic and biomedical science, miRNA research will have a revolutionary impact on the management of osteosarcoma.
骨肉瘤是一种主要发生于儿童和青少年的原发性恶性骨肿瘤，发病率较高。虽然骨肉瘤的分子基础已受到广泛关注，但术前和术后转移形成及化疗耐药性发展的细胞和分子机制仍不清楚。微小RNA（miRNA）是一类由22个核苷酸组成的非编码RNA，已成为控制众多重要病理生理过程（包括癌症的发生和发展）的基因调控网络的关键组成部分。对miRNA的研究为癌症的诊断和治疗开辟了新途径。本文综述了miRNA在骨肉瘤中的作用及其在该恶性肿瘤诊断、预后和治疗中的潜在应用。作为基础和生物医学科学中一个快速发展的领域，miRNA研究将对骨肉瘤的治疗产生革命性影响。
