Division of Cardiothoracic Surgery, Southern Illinois University School of Medicine, 701 N First St, PO Box 19638, Springfield, IL 62794-9638, USA.
Circulation. 2013 May 7;127(18):1870-6. doi: 10.1161/CIRCULATIONAHA.113.002200. Epub 2013 Apr 8.
Despite the established superiority of mitral repair over replacement, its adoption in the treatment of elderly patients has not been uniform, partly because of a lack of robust long-term survival data. We present the long-term survival of Medicare fee-for-service beneficiaries undergoing mitral valve repair and replacement over a 10-year period.
We used the Medicare database to identify 47 279 fee-for-service beneficiaries ≥65 years of age undergoing primary isolated mitral valve repair or replacement from 2000 to 2009. Operative mortality and long-term survival are presented for repair and replacement. Operative mortality was 3.9% for patients undergoing repair and 8.9% for patients undergoing replacement. The 1-, 5-, and 10-year Kaplan-Meier survival estimates for patients undergoing repair were 90.9%, 77.1%, and 53.6%. The 1-, 5-, and 10-year Kaplan-Meier survival estimates for patients undergoing replacement were 82.6%, 64.7%, and 37.2%. Important predictors of mitral repair included younger age (odds ratio, 1.10; 95% confidence interval, 1.05-1.14), elective admission status (odds ratio, 1.34; 95% confidence interval, 1.27-1.41), and annual mitral procedure volume >40 cases per year (odds ratio, 1.57; 95% confidence interval, 1.36-1.81). Female sex and the presence of comorbidities were associated with a lower likelihood of repair.
Mitral valve surgery in the Medicare population carries less risk than previously reported. Given the favorable outcomes of elderly patients undergoing mitral valve surgery, especially mitral valve repair, an approach of earlier identification and surgical referral appears justified regardless of age.
尽管二尖瓣修复术在治疗二尖瓣疾病方面已被证实优于置换术,但在老年患者中的应用并不统一,部分原因是缺乏长期生存的有力数据。我们报告了在过去 10 年中,接受二尖瓣修复术和置换术的医疗保险付费患者的长期生存情况。
我们使用医疗保险数据库,确定了 2000 年至 2009 年期间 47279 名年龄在 65 岁以上、接受单纯二尖瓣修复或置换术的医疗保险付费患者。报告了修复术和置换术的手术死亡率和长期生存率。修复术患者的手术死亡率为 3.9%,置换术患者为 8.9%。修复术患者的 1 年、5 年和 10 年 Kaplan-Meier 生存估计值分别为 90.9%、77.1%和 53.6%。置换术患者的 1 年、5 年和 10 年 Kaplan-Meier 生存估计值分别为 82.6%、64.7%和 37.2%。二尖瓣修复的重要预测因素包括年龄较小(比值比,1.10;95%置信区间,1.05-1.14)、择期入院状态(比值比,1.34;95%置信区间,1.27-1.41)和每年二尖瓣手术量>40 例(比值比,1.57;95%置信区间,1.36-1.81)。女性和合并症的存在与修复术的可能性降低相关。
医疗保险人群中的二尖瓣手术风险低于先前报告的风险。鉴于老年患者接受二尖瓣手术的良好结局,尤其是二尖瓣修复术,无论年龄大小,早期识别和手术转诊似乎都是合理的。