裸花紫珠叶提取物的抗炎活性
Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees.
作者信息
Saleem T K Mohamed, Azeem A K, Dilip C, Sankar C, Prasanth N V, Duraisami R
机构信息
Al Shifa College of Pharmacy, Poonthavanam P.O, Kizhattur, Perinthalmanna, Malappuram dist, Kerala, India 679329.
出版信息
Asian Pac J Trop Biomed. 2011 Apr;1(2):147-9. doi: 10.1016/S2221-1691(11)60014-2.
OBJECTIVE
To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris (G. vulgaris) Nees.
METHODS
G. vulgaris Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala.Various parts of this plant have been used in the treatment of ulcers, sores, inflammation, dyspepsia, healing of wounds, etc. The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation (HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.
RESULTS
Both the methods showed significant anti-inflammatory property of the different extracts tested.
CONCLUSIONS
The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium.
目的
评估假杜鹃（Gendarussa vulgaris (G. vulgaris) Nees）叶提取物的抗炎特性。
方法
夹竹桃科的假杜鹃是一种中型树木，生长在半阴或无荫处，在喀拉拉邦的埃尔纳德和尼尔阿姆布尔 taluks 很常见。该植物的各个部位已被用于治疗溃疡、疮、炎症、消化不良、伤口愈合等。本研究旨在通过体外和体内方法评估叶水提取物和醇提取物的抗炎特性。体外方法通过人红细胞膜稳定（HRBC）法评估，体内方法通过角叉菜胶诱导的爪肿胀评估。
结果
两种方法均显示所测试的不同提取物具有显著的抗炎特性。
结论
与标准药物双氯芬酸钠相比，浓度为 300 mg/mL 的醇提取物显示出强效活性。
Zotero 插件