Eskelinen M, Collán Y, Pesonen E, Salonen J T
Department of Surgery, University Central Hospital, Kuopio, Finland.
Ann Chir Gynaecol. 1990;79(1):10-4.
Risk factors in breast cancer were analysed in a series of 293 women who were first seen at the Surgical Outpatient Department of Savonlinna Central Hospital in 1982-1983 for breast problems and were alive and willing to participate in a control examination and interview 4-5 years later. In 1986 and 1987 the patients were examined clinically and underwent mammography and interview. They were divided into three groups: 1) 49 patients with breast cancer in 1982 and 1983, 2) 49 with breast symptoms after primary treatment of benign disease, and 3) 195 patients without breast symptoms after primary treatment of benign disease. The groups were compared in terms of 18 suggested risk factors for breast cancer. Two factors were significantly associated with breast cancer (compared with all benign breast diseases): higher age of the patient and higher age at first delivery. Use of contraceptives was significantly associated with the presence of breast symptoms after treatment of benign breast disease (as compared with the absence of symptoms) (RR = 1.70 P less than 0.001). Hysterectomy and/or oophorectomy was significantly associated with the absence of breast symptoms among patients with benign breast disease (RR = 0.76, P less than 0.05). Our results suggest that symptoms after treatment of benign breast disease are associated with the levels of female sex hormones.
对1982年至1983年首次在萨翁林纳中央医院外科门诊因乳腺问题就诊的293名女性进行了乳腺癌风险因素分析，这些女性在4至5年后仍然存活且愿意参加对照检查和访谈。1986年和1987年，对这些患者进行了临床检查、乳房X光检查并进行了访谈。她们被分为三组：1）1982年和1983年患有乳腺癌的49名患者；2）良性疾病初次治疗后有乳腺症状的49名患者；3）良性疾病初次治疗后无乳腺症状的195名患者。对这三组患者就18种提示的乳腺癌风险因素进行了比较。有两个因素与乳腺癌显著相关（与所有良性乳腺疾病相比）：患者年龄较大和首次分娩年龄较大。使用避孕药与良性乳腺疾病治疗后出现乳腺症状显著相关（与无症状相比）（相对危险度=1.70，P<0.001）。子宫切除术和/或卵巢切除术与良性乳腺疾病患者无乳腺症状显著相关（相对危险度=0.76，P<0.05）。我们的结果表明，良性乳腺疾病治疗后的症状与女性性激素水平有关。
