通过振动喷嘴和乳液相转化技术对亲水分子模型的微胶囊化。

Microencapsulation of a hydrophilic model molecule through vibration nozzle and emulsion phase inversion technologies.

机构信息

Department of Drug Sciences, University of Pavia, Italy.

出版信息

J Microencapsul. 2013;30(6):559-70. doi: 10.3109/02652048.2013.764938. Epub 2013 Apr 9.

DOI:10.3109/02652048.2013.764938

PMID:23570546

Abstract

INTRODUCTION

The goal of the present work was to evaluate and discuss vibration nozzle microencapsulation (VNM) technology combined to lyophilization, for the microencapsulation of a hydrophilic model molecule into a hydrophilic polymer.

MATERIALS AND METHODS

Fluorescein-loaded alginate microparticles prepared by VNM and emulsion phase inversion microencapsulation (EPIM) were lyophilized. Morphology, particle size distribution, lyophilized microspheres stability upon rehydration, drug loading and in vitro release were evaluated.

RESULTS AND DISCUSSION

Well-formed microspheres were obtained by the VNM technique, with higher yields of production (93.3-100%) and smaller particle size (d50138.10-158.00) than the EPIM microspheres. Rehydration upon lyophilization occurred in 30 min maintaining microsphere physical integrity. Fluorescein release was always faster from the microspheres obtained by VNM (364 h) than from those obtained by EPIM (504 h).

CONCLUSION

The results suggest that VNM is a simple, easy to be scaled-up process suitable for the microencapsulation hydrophilic drugs.

摘要

简介

本工作的目的是评估和讨论振动喷嘴微囊化（VNM）技术与冷冻干燥相结合，用于将亲水性模型分子包封到亲水性聚合物中。

材料与方法

通过 VNM 和乳液相转化微囊化（EPIM）制备载有荧光素的海藻酸钠微球，进行冷冻干燥。评估形态、粒径分布、复水时的冻干微球稳定性、载药量和体外释放。

结果与讨论

通过 VNM 技术获得了形态良好的微球，具有更高的产率（93.3-100%）和更小的粒径（d50138.10-158.00）比 EPIM 微球。冷冻干燥后的复水在 30 分钟内完成，保持了微球的物理完整性。通过 VNM 获得的微球的荧光素释放始终比通过 EPIM 获得的微球快（364 h 比 504 h）。