接种疫苗的生长鸡中的AA型淀粉样变性

AA amyloidosis in vaccinated growing chickens.

作者信息

Murakami T, Inoshima Y, Sakamoto E, Fukushi H, Sakai H, Yanai T, Ishiguro N

机构信息

Laboratory of Food and Environmental Hygiene, Department of Veterinary Medicine, Gifu University, Gifu, Japan.

出版信息

J Comp Pathol. 2013 Aug-Oct;149(2-3):291-7. doi: 10.1016/j.jcpa.2013.02.002. Epub 2013 Apr 6.

DOI:10.1016/j.jcpa.2013.02.002

PMID:23570943

Abstract

Systemic amyloid-A (AA) amyloidosis in birds occurs most frequently in waterfowl such as Pekin ducks. In chickens, AA amyloidosis is observed as amyloid arthropathy. Outbreaks of systemic amyloidosis in flocks of layers are known to be induced by repeated inflammatory stimulation, such as those resulting from multiple vaccinations with oil-emulsified bacterins. Outbreaks of fatal AA amyloidosis were observed in growing chickens in a large scale poultry farm within 3 weeks of vaccination with multiple co-administered vaccines. This study documents the histopathological changes in tissues from these birds. Amyloid deposits were also observed at a high rate in the tissues of apparently healthy chickens. Vaccination should therefore be considered as a potential risk factor for the development of AA amyloidosis in poultry.

摘要

鸟类全身性淀粉样蛋白A（AA）淀粉样变性最常发生于水禽，如北京鸭。在鸡中，AA淀粉样变性表现为淀粉样关节病。已知蛋鸡群中全身性淀粉样变性的暴发是由反复的炎症刺激诱发的，例如多次接种油乳剂菌苗所导致的炎症刺激。在一家大型家禽养殖场，生长鸡在接种多种联合疫苗后3周内出现了致命性AA淀粉样变性的暴发。本研究记录了这些鸟类组织的组织病理学变化。在看似健康的鸡的组织中也发现了高比例的淀粉样沉积物。因此，疫苗接种应被视为家禽发生AA淀粉样变性的一个潜在风险因素。