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Curr Opin Chem Biol. 2013 Jun;17(3):406-11. doi: 10.1016/j.cbpa.2013.03.022. Epub 2013 Apr 6.
Antibody-drug conjugates (ADCs) require multiple assays for analytical and bioanalytical characterization due to their heterogeneous and dynamic nature. These assays can help address questions from the drug-loading distribution following conjugation to exposure-response relationships after dosing in vivo. This review describes new assay technologies that have been developed for physiochemical characterization and determination of pharmacokinetic parameters of ADCs.
抗体偶联药物（ADCs）由于其异质性和动态特性，需要进行多种分析和生物分析特性鉴定检测。这些检测有助于解决从偶联后药物载量分布到体内给药后暴露-反应关系等问题。本文综述了新的检测技术，这些技术已经被开发出来用于 ADC 的物理化学特性分析和药代动力学参数的测定。
