Department of Population Health, New York University School of Medicine, New York, New York, USA.
J Pain Symptom Manage. 2013 Nov;46(5):640-51. doi: 10.1016/j.jpainsymman.2012.11.007. Epub 2013 Apr 6.
Nursing home (NH) residents with advanced dementia commonly experience burdensome and costly hospitalizations that may not extend survival or improve quality of life. Cost-effectiveness analyses of decisions to hospitalize these residents have not been reported.
To estimate the cost-effectiveness of 1) not having a do-not-hospitalize (DNH) order and 2) hospitalization for suspected pneumonia in NH residents with advanced dementia.
NH residents from 22 NHs in the Boston area were followed in the Choices, Attitudes, and Strategies for Care of Advanced Dementia at the End-of-Life study conducted between February 2003 and February 2009. We conducted cost-effectiveness analyses of aggressive treatment strategies for advanced dementia residents living in NHs when they suffer from acute illness. Primary outcome measures included quality-adjusted life days (QALD) and quality-adjusted life years, Medicare expenditures, and incremental net benefits (INBs) over 15 months.
Compared with a less aggressive strategy of avoiding hospital transfer (i.e., having DNH orders), the strategy of hospitalization was associated with an incremental increase in Medicare expenditures of $5972 and an incremental gain in quality-adjusted survival of 3.7 QALD. Hospitalization for pneumonia was associated with an incremental increase in Medicare expenditures of $3697 and an incremental reduction in quality-adjusted survival of 9.7 QALD. At a willingness-to-pay level of $100,000/quality-adjusted life years, the INBs of the more aggressive treatment strategies were negative and, therefore, not cost effective (INB for not having a DNH order, -$4958 and INB for hospital transfer for pneumonia, -$6355).
Treatment strategies favoring hospitalization for NH residents with advanced dementia are not cost effective.
患有晚期痴呆症的养老院(NH)居民经常经历负担沉重且昂贵的住院治疗,这些治疗可能无法延长生存时间或改善生活质量。尚未报告对这些居民进行住院治疗决策的成本效益分析。
估计 1)不制定不转院(DNH)医嘱和 2)对患有晚期痴呆症的 NH 居民疑似肺炎进行住院治疗的成本效益。
2003 年 2 月至 2009 年 2 月期间,在波士顿地区的 22 家 NH 中,对 Choices、Attitudes、and Strategies for Care of Advanced Dementia at the End-of-Life 研究中的 NH 居民进行了随访。我们对 NH 中患有晚期痴呆症的居民在急性疾病时的激进治疗策略进行了成本效益分析。主要结局指标包括质量调整生命天数(QALD)和质量调整生命年、医疗保险支出以及 15 个月内的增量净收益(INB)。
与避免转院的较不激进策略(即制定 DNH 医嘱)相比,住院策略与医疗保险支出的增量增加了 5972 美元,质量调整后的生存增益增量为 3.7 QALD。肺炎住院与医疗保险支出的增量增加了 3697 美元,质量调整后的生存减少了 9.7 QALD。在愿意支付 10 万美元/质量调整生命年的水平下,更激进的治疗策略的增量净收益为负,因此不具有成本效益(不制定 DNH 医嘱的增量净收益为-4958 美元,因肺炎转院的增量净收益为-6355 美元)。
支持对患有晚期痴呆症的 NH 居民进行住院治疗的治疗策略不具有成本效益。