在旧金山，HIV 阴性的男男性行为者（MSM）中，物质使用的数量和频率与高危性行为之间的剂量反应关系。
Dose-response associations between number and frequency of substance use and high-risk sexual behaviors among HIV-negative substance-using men who have sex with men (SUMSM) in San Francisco.
机构信息
San Francisco Department of Public Health, San Francisco, CA 94102, USA.
出版信息
J Acquir Immune Defic Syndr. 2013 Aug 1;63(4):540-4. doi: 10.1097/QAI.0b013e318293f10b.
Abstract
We evaluated the relationship between frequency and number of substances used and HIV risk [ie, serodiscordant unprotected anal intercourse (SDUAI)] among 3173 HIV-negative substance-using MSM. Compared with nonusers, the adjusted odds ratio (AOR) for SDUAI among episodic and at least weekly users, respectively, was 3.31 [95% confidence interval (CI), 2.55 to 4.28] and 5.46 (95% CI, 3.80 to 7.84) for methamphetamine, 1.86 (95% CI, 1.51 to 2.29) and 3.13 (95% CI, 2.12 to 4.63) for cocaine, and 2.08 (95% CI, 1.68 to 2.56) and 2.54 (95% CI, 1.85 to 3.48) for poppers. Heavy alcohol drinkers reported more SDUAI than moderate drinkers [AOR, 1.90 (95% CI, 1.43 to 2.51)]. Compared with nonusers, AORs for using 1, 2, and ≥3 substances were 16.81 (95% CI, 12.25 to 23.08), 27.31 (95% CI, 18.93 to 39.39), and 46.38 (95% CI, 30.65 to 70.19), respectively. High-risk sexual behaviors were strongly associated with frequency and number of substances used.
摘要
我们评估了 3173 名 HIV 阴性的滥用药物男男性行为者中，使用物质的频率和数量与 HIV 风险（即血清不一致的无保护肛交）之间的关系。与非使用者相比，在物质使用的发作性和每周至少一次使用者中，与 SDUAI 相关的调整后比值比（AOR）分别为 3.31（95%可信区间[CI]，2.55 至 4.28）和 5.46（95%CI，3.80 至 7.84）用于甲基苯丙胺，1.86（95%CI，1.51 至 2.29）和 3.13（95%CI，2.12 至 4.63）用于可卡因，2.08（95%CI，1.68 至 2.56）和 2.54（95%CI，1.85 至 3.48）用于催泪瓦斯。大量饮酒者报告的 SDUAI 比中度饮酒者多[AOR，1.90（95%CI，1.43 至 2.51）]。与非使用者相比，使用 1、2 和≥3 种物质的 AOR 分别为 16.81（95%CI，12.25 至 23.08）、27.31（95%CI，18.93 至 39.39）和 46.38（95%CI，30.65 至 70.19）。高危性行为与使用物质的频率和数量密切相关。
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