Bartoli F, Paradies G, Virgintino D, Leggio A, Roncali L
Cattedra di Chirurgia Pediatrica, Facoltà di Medicina e Chirurgia dell'Università di Bari.
Boll Soc Ital Biol Sper. 1990 Feb;66(2):181-8.
The ureter structure was analyzed under light microscope on serial sections in newborn children affected by obstruction of the pyelo-ureteric junction. In the obstructive segments, preceded by ureter portions dilated and provided with close-packed layers of smooth muscle layers, the tunica mucosa was lacking epithelial cover, its lamina propria was thickened, being built by conspicuous bundles of collagen fibers, and the tunica muscularis showed scarce and disrupted groups of muscle cells invaded by connective tissue. Numerous mastocytes were seen in the mucosa and muscularis tunicae. The results suggest that the breaking of the epithelium may be a primary pathogenetic event followed by passage of urine in the subjacent tissues in turn responsible for a diffuse connective reaction, and, therefore for a final fibrosis of the ureter wall. The role of the mastocytes in the etiopathogenesis of the pyelo-ureteric junction obstruction was also discussed.
对患有肾盂输尿管连接部梗阻的新生儿连续切片进行光镜下输尿管结构分析。在梗阻段，其前方的输尿管部分扩张并具有紧密排列的平滑肌层，黏膜层缺乏上皮覆盖，固有层增厚，由明显的胶原纤维束构成，肌层可见稀少且中断的肌细胞群，并有结缔组织侵入。在黏膜和肌层可见大量肥大细胞。结果表明，上皮破裂可能是原发性致病事件，随后尿液进入下方组织，进而引发弥漫性结缔组织反应，最终导致输尿管壁纤维化。还讨论了肥大细胞在肾盂输尿管连接部梗阻病因学中的作用。
