Routray S, Sunkavali A, Bari K A
Department of Oral Pathology & Microbiology, GITAM Dental College & Hospital, Vishakapatanam, India.
Oral Dis. 2014 Apr;20(3):246-53. doi: 10.1111/odi.12107. Epub 2013 Apr 11.
The communication between tumor stromal and parenchymal cells provides an insight to tumor progression. One of the main elements of the stroma, a major contributor to the extracellular environment of tumors, is carcinoma-associated fibroblasts. They can originate from either normal fibroblasts in the immediate vicinity of the tumor or from circulating bone marrow-derived mesenchymal stem cells. These myofibroblasts can arise locally from an endothelial-mesenchymal transformation at the invasive edge of the cancer and are physically associated with carcinoma cells, that is, in the development of high-grade malignancies and poor prognosis. These carcinoma-associated fibroblasts feed the epithelial tumor cells in a host-parasite relationship establishing its role in head and neck squamous cell carcinoma progression.
肿瘤基质细胞与实质细胞之间的通讯为肿瘤进展提供了线索。基质的主要成分之一，也是肿瘤细胞外环境的主要贡献者，是癌相关成纤维细胞。它们可以起源于肿瘤附近的正常成纤维细胞，也可以起源于循环中的骨髓来源间充质干细胞。这些肌成纤维细胞可局部源自癌症侵袭边缘的内皮-间充质转化，并与癌细胞存在物理关联，即在高级别恶性肿瘤的发生发展及预后不良中发挥作用。这些癌相关成纤维细胞以宿主-寄生虫关系为上皮肿瘤细胞提供养分，在头颈部鳞状细胞癌进展中发挥作用。
