Lee Sung Ryol, Kim Hyung Ook, Son Byung Ho, Yoo Chang Hak, Shin Jun Ho
Department of Surgery, Kangbuk Samskung Hospital, Sungkyunkwan University School of Medicine, Seoul, South Korea.
Hepatogastroenterology. 2013 Mar-Apr;60(122):358-62. doi: 10.5754/hge12727.
BACKGROUND/AIMS: It is very important to determine the prognostic factors for pancreatic adenocarcinoma when choosing surgical and conservative management strategies. In this study, we identified prognostic factors for survival and recurrence in patients with histologically proven pancreatic adenocarcinoma.
Between January 2003 and December 2009, 82 patients with histologically proven pancreatic adenocarcinoma were considered for this study. Follow-up consisted of personal contact with patients or review of electronic medical records at this center and was terminated on December 31, 2011 or upon the patient's death.
Overall survival rates of all patients at 1, 3, and 5 years were 51.9, 21.6 and 16.0%. Preoperative jaundice was the only independent prognostic factor for total pancreatic cancer patients, while N stage and perineural invasion in pathological findings was identified as an independent prognostic factor for survival of patients with surgical resection. Chemotherapy was the only independent prognostic factor for survival of patients who underwent palliative surgical bypass.
Preoperative jaundice in any patients, lymph node metastasis, perineural invasion in patients with surgical resection, and chemotherapy in patients undergoing palliative surgical bypass are important prognostic factors for survival of pancreatic cancer.
背景/目的：在选择手术和保守治疗策略时，确定胰腺腺癌的预后因素非常重要。在本研究中，我们确定了经组织学证实的胰腺腺癌患者生存和复发的预后因素。
2003年1月至2009年12月期间，本研究纳入了82例经组织学证实的胰腺腺癌患者。随访包括与患者个人联系或查阅本中心的电子病历，并于2011年12月31日或患者死亡时终止。
所有患者1年、3年和5年的总生存率分别为51.9%、21.6%和16.0%。术前黄疸是所有胰腺癌患者唯一的独立预后因素，而病理检查中的N分期和神经周围侵犯被确定为手术切除患者生存的独立预后因素。化疗是接受姑息性手术旁路治疗患者生存的唯一独立预后因素。
任何患者的术前黄疸、手术切除患者中的淋巴结转移、神经周围侵犯以及接受姑息性手术旁路治疗患者的化疗是胰腺癌生存的重要预后因素。
