Department of Radiation Oncology, Stanford University, Stanford, CA, USA.
Int J Clin Oncol. 2013 Jun;18(3):359-63. doi: 10.1007/s10147-013-0556-3. Epub 2013 Apr 11.
Radiation techniques for the treatment of Hodgkin's disease have evolved dramatically in the past century. Shortly after the discovery of X-rays, the lymphomas in general, and Hodgkin's disease in particular, were noted to be radiosensitive. However, equipment limitations restricted the ability to administer sufficient doses to adequate depth to ensure long-term control. This situation improved sequentially with the development of the Coolidge tube, (60)Co machine, and medical linear accelerators. With megavoltage radiation it was possible to demonstrate cures of stage I-II disease with high-dose extended-field irradiation. When combined modality therapy programs were introduced, this permitted restriction of radiation fields and doses in order to decrease toxicity. Innovative advanced technologies such as PET simulation, 3-D treatment planning, intensity-modulated radiotherapy, active breathing control, and proton therapy have further improved the outcomes for patients treated with irradiation.
在过去的一个世纪中，放射治疗霍奇金病的技术有了显著的发展。在发现 X 射线后不久，人们就注意到一般的淋巴瘤，特别是霍奇金病，对放射敏感。然而，设备的限制限制了给予足够剂量并达到足够深度以确保长期控制的能力。随着 Coolidge 管、（60）Co 机和医用线性加速器的发展，这种情况逐渐得到改善。使用兆伏级射线，有可能通过大剂量扩展野照射治愈 I 期-II 期疾病。当引入联合治疗方案时，这允许限制放射野和剂量，以降低毒性。创新的先进技术，如 PET 模拟、3-D 治疗计划、强度调制放疗、主动呼吸控制和质子治疗，进一步改善了接受放疗的患者的治疗效果。
