快速眼动睡眠剥夺后脑桥单位活动的变化。
Changes in pontine unit activity with REM sleep deprivation.
作者信息
Mallick B N, Siegel J M, Fahringer H
机构信息
Neurobiology Research, Sepulveda V.A. Medical Center, CA 91343.
出版信息
Brain Res. 1990 May 7;515(1-2):94-8. doi: 10.1016/0006-8993(90)90581-u.
Abstract
Short term rapid eye movement (REM) sleep deprivation produced a decrease in walking discharge rates of presumably noradrenergic pontine 'REM sleep-off' cells and an increase in waking discharge rates of pontine 'REM sleep-on' cells. These changes can be viewed as a correlate of increased REM sleep pressure. Slowing of REM sleep-off cells in waking is hypothesized to counteract the functional effects of REM sleep loss on noradrenergic receptor sensitivity. This slowing and the resulting reduction in norepinephrine release may contribute to the loss of vigilance seen with sleep deprivation.
摘要
短期快速眼动（REM）睡眠剥夺导致推测为去甲肾上腺素能脑桥“REM睡眠关闭”细胞的放电率下降，以及脑桥“REM睡眠开启”细胞的清醒放电率增加。这些变化可被视为REM睡眠压力增加的一个相关因素。据推测，清醒时REM睡眠关闭细胞的减慢可抵消REM睡眠缺失对去甲肾上腺素能受体敏感性的功能影响。这种减慢以及由此导致的去甲肾上腺素释放减少可能导致睡眠剥夺时出现的警觉性丧失。
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