Division of Nephrology, First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, Yunnan Province, China.
Int Urol Nephrol. 2013 Dec;45(6):1621-7. doi: 10.1007/s11255-013-0431-1. Epub 2013 Apr 11.
Chronic kidney disease (CKD) is associated with high overall and cardiovascular mortality. Numerous studies have reported that increased heart rate is a risk factor for all-cause mortality. We investigated the link between sleep heart rate and artery stiffness in CKD patients.
In a cross-sectional study, we enrolled 100 prevalent Chinese CKD patients (55 males, aged 52.5 ± 16.40 years). Heart rate was measured with an automatic system. Arterial stiffness was evaluated by using a calibrated tonometer.
Large artery elasticity index (LAEI) was positively correlated with body mass index and hemoglobin but negatively associated with age and systolic blood pressure. Furthermore, LAEI was negatively associated with glomerular filtration rate (GFR) and sleep heart rate. In multivariate regression, LAEI was independently predicted by SBP, BMI, age, sleep heart rate, and gender. Adjusted R (2) of the model was 0.486.
Elevated sleep heart rate is significantly associated with increased arterial stiffness in CKD patients. Further investigation is needed to explore the potential benefits of sleep heart rate lowering therapy in this patient group.
慢性肾脏病（CKD）与较高的总死亡率和心血管死亡率相关。许多研究报告称，心率增快是全因死亡率的一个危险因素。我们研究了 CKD 患者的睡眠心率与动脉僵硬之间的关系。
在一项横断面研究中，我们纳入了 100 例中国 CKD 患者（55 名男性，年龄 52.5±16.40 岁）。使用自动系统测量心率。使用校准的张力计评估动脉僵硬。
大动脉弹性指数（LAEI）与体重指数和血红蛋白呈正相关，与年龄和收缩压呈负相关。此外，LAEI 与肾小球滤过率（GFR）和睡眠心率呈负相关。在多元回归中，LAEI 独立地由 SBP、BMI、年龄、睡眠心率和性别预测。模型的调整 R²为 0.486。
升高的睡眠心率与 CKD 患者的动脉僵硬增加显著相关。需要进一步研究以探讨降低睡眠心率治疗在该患者群体中的潜在获益。
