非透析期5期慢性肾脏病患者的血清内脂素与昼夜心率变异性
Serum endocan and circadian heart rate variability in non-dialysis stage 5 chronic kidney disease patients.
作者信息
Bao Yu, Wang Yi-An, Xiao Hua, Wang Ying, Wu Yan, Yan Yue, Zhu Zhu, Ni Mei, Pi Cheng-Xian, Liu Ming-Yue, Yang Jun-Hua, Li Yan-Ting, Tian Xin-Kui, Wang Tao, Zhe Xing-Wei
机构信息
Division of Nephrology, The First Affiliated Hospital of Kunming Medical University, 295 Xichang Road, Kunming, 650032, China.
Division of Nephrology, The Second Affiliated Hospital of Kunming Medical University, Kunming, China.
出版信息
Int Urol Nephrol. 2018 Nov;50(11):2061-2066. doi: 10.1007/s11255-018-1993-8. Epub 2018 Oct 1.
BACKGROUND
Chronic kidney disease (CKD) is very common now and is associated with high overall and cardiovascular mortality. Numerous studies have reported that elevated heart rate (HR) is a risk factor for cardiovascular mortality. We investigated the link between serum endocan and circadian heart rate variability in non-dialysis stage 5 CKD patients.
METHODS
In a cross-sectional study, we enrolled 54 prevalent n non-dialysis stage 5 CKD patients (32 males, aged 48.2 ± 14.92 years). HR was measured with an automatic system. Serum endocan level was analyzed by ELISA.
RESULTS
Night/day HR ratio was independently predicted by serum endocan level (P < 0.01) and hypertension history (P < 0.05). Adjusted R of the model was 0.222.
CONCLUSION
Increased serum endocan is significantly associated with circadian heart rate variability in non-dialysis stage 5 CKD patients. Further investigation is needed to explore the potential benefits of serum endocan lowering therapy in this patient group.
背景
慢性肾脏病（CKD）目前非常常见，且与总体及心血管疾病高死亡率相关。众多研究报告称，心率（HR）升高是心血管疾病死亡的一个危险因素。我们调查了非透析5期CKD患者血清内脂素与昼夜心率变异性之间的联系。
方法
在一项横断面研究中，我们纳入了54例非透析5期CKD患者（32例男性，年龄48.2±14.92岁）。使用自动系统测量心率。通过酶联免疫吸附测定法分析血清内脂素水平。
结果
血清内脂素水平（P<0.01）和高血压病史（P<0.05）可独立预测夜间/日间心率比值。该模型的调整R为0.222。
结论
血清内脂素升高与非透析5期CKD患者的昼夜心率变异性显著相关。需要进一步研究以探索降低血清内脂素治疗对该患者群体的潜在益处。
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