Jorde Rolf, Strand Hutchinson Moira, Kjærgaard Marie, Sneve Monica, Grimnes Guri
Tromsø Endocrine Research Group, Department of Clinical Medicine, University of Tromsø, 9037 Tromsø, Norway ; Division of Internal Medicine, University Hospital of North Norway, 9038 Tromsø, Norway.
ISRN Endocrinol. 2013;2013:348705. doi: 10.1155/2013/348705. Epub 2013 Mar 14.
Data were pooled from four randomized clinical trials with vitamin D performed in Tromsø with weight reduction, insulin sensitivity, bone density, and depression scores as endpoints. Serum lipids, glycated hemoglobin (HbA1c), and high sensitivity C-Reactive Protein, (HS-CRP) were measured at baseline and after 6-12 months of supplementation with vitamin D 20 000 IU-40 000 IU per week versus placebo. A total of 928 subjects who completed the interventions were included. At baseline the mean serum 25-hydroxyvitamin D (25(OH)D) level in those given vitamin D was 55.9 (20.9) nmol/L and the mean increase was 82.4 (40.1) nmol/L. Compared with the placebo group there was in the vitamin D group at the end of the studies a slight, but significant, increase in HbA1c of 0.04%, an increase in HS-CRP of 0.07 mg/L in those with serum 25(OH)D < 50 nmol/L, and in those with low baseline HDL-C and serum 25(OH)D < 50 nmol/L a slight decrease serum HDL-C of 0.08 mmol/L (P < 0.05). No serious side-effects were seen. In conclusion, in subjects without vitamin D deficiency, there is no improvement in serum lipids, HbA1c, or HS-CRP with high dose vitamin D supplementation. If anything, the effect is negative.
数据来自于在特罗姆瑟进行的四项关于维生素D的随机临床试验，这些试验以体重减轻、胰岛素敏感性、骨密度和抑郁评分作为终点。在基线以及每周补充20000国际单位至40000国际单位维生素D与安慰剂对比6至12个月后，测量血清脂质、糖化血红蛋白（HbA1c）和高敏C反应蛋白（HS-CRP）。总共纳入了928名完成干预的受试者。在基线时，给予维生素D的受试者血清25-羟基维生素D（25(OH)D）水平的平均值为55.9（20.9）nmol/L，平均增加量为82.4（40.1）nmol/L。与安慰剂组相比，在研究结束时，维生素D组的HbA1c轻微但显著增加了0.04%，血清25(OH)D < 50 nmol/L的受试者中HS-CRP增加了0.07 mg/L，而基线高密度脂蛋白胆固醇（HDL-C）低且血清25(OH)D < 50 nmol/L的受试者血清HDL-C轻微降低了0.08 mmol/L（P < 0.05）。未观察到严重的副作用。总之，在没有维生素D缺乏的受试者中，高剂量补充维生素D对血清脂质、HbA1c或HS-CRP没有改善作用。如果有任何影响的话，其效果是负面的。
