Matheny J L, Weisman C, Karow A M, Shlafer M
Res Commun Chem Pathol Pharmacol. 1975 Jan;10(1):77-92.
Electrically driven rabbit left atria were exposed to 20 min periods of hypoxia in the presence and absence of dimethyl sulfoxide (DMSO) or sucrose. Contractile strength declined significantly less than control when tissues were exposed to DMSO during hypoxia. On reoxygenation tissues treated with DMSO recovered pre-hypoxia contractile strength more slowly. Sucrose did not protect tissues during hypoxia. Comparison of results with DMSO and sucrose indicated that tissue depression prior to hypoxia could not explain the action of DMSO. Kinetic analysis performed on tension decline which occurred during hypoxia showed that two components were involved; rate of tension loss in both components was decreased by DMSO and there was a shift in the percentage of decline to the slower component. These data indicate that DMSO may increase energy availability, increase efficiency of energy utilization, or possibly affect the shift from aerobic to anaerobic metabolism during hypoxia, but not during the post-hypoxic recovery period.
将电驱动的兔左心房在有和没有二甲基亚砜（DMSO）或蔗糖的情况下暴露于20分钟的缺氧环境中。当组织在缺氧期间暴露于DMSO时，收缩强度的下降明显小于对照组。复氧时，用DMSO处理的组织恢复缺氧前收缩强度的速度较慢。蔗糖在缺氧期间不能保护组织。DMSO和蔗糖结果的比较表明，缺氧前的组织抑制不能解释DMSO的作用。对缺氧期间发生的张力下降进行的动力学分析表明，涉及两个成分；DMSO降低了两个成分中张力损失的速率，并且下降百分比向较慢的成分转移。这些数据表明，DMSO可能会增加能量供应，提高能量利用效率，或者可能影响缺氧期间从有氧代谢向无氧代谢的转变，但在缺氧后恢复期不会。
