腹腔镜脾活检——从猪到人的研究——使用纤维蛋白密封剂技术
Laparoscopic splenic biopsy--porcine to human studies--using a fibrin sealant technique.
作者信息
Hui Kei Yiu Douglas, Robinson Stuart M, Amer Aimen, Wallis Jonathan P, White Steven A
机构信息
Department of Hepatopancreatobiliary and Transplantation Surgery, The Freeman Hospital, Newcastle Upon Tyne, Tyne and Wear, UK.
出版信息
Surg Laparosc Endosc Percutan Tech. 2013 Apr;23(2):e54-6. doi: 10.1097/SLE.0b013e318272fd01.
INTRODUCTION
Splenic biopsies are not routinely performed because of the risk of severe hemorrhage. The aim of this study was to explore the feasibility of performing laparoscopic splenic biopsies using a fibrin sealant in pigs and then to translate this technique into the clinical setting.
METHOD
Four German Landrace pigs underwent a laparoscopic splenic biopsy using a fibrin sealant to occlude the needle tract. Time to achieve hemostasis and postoperative hemorrhage were assessed.
RESULT
The average time to achieve haemostasis was 15 s (range, 8 to 25 s) with no hemorrhage from the needle tract observed. Subsequently this was translated into the clinical setting where a patient also underwent a laparoscopic splenic biopsy without any adverse effect.
CONCLUSIONS
Laparoscopic splenic biopsy with the application of a fibrin sealant is a safe and efficient technique.
引言
由于存在严重出血风险，脾脏活检通常不常进行。本研究的目的是探讨在猪身上使用纤维蛋白密封剂进行腹腔镜脾脏活检的可行性，然后将该技术应用于临床。
方法
对4头德国长白猪进行腹腔镜脾脏活检，使用纤维蛋白密封剂封闭针道。评估止血时间和术后出血情况。
结果
平均止血时间为15秒（范围为8至25秒），未观察到针道出血。随后将该技术应用于临床，一名患者也接受了腹腔镜脾脏活检，未出现任何不良反应。
结论
应用纤维蛋白密封剂进行腹腔镜脾脏活检是一种安全有效的技术。
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