Idrus Nirelia M, Thomas Jennifer D
Center for Behavioral Teratology, Department of Psychology, San Diego State University, San Diego, California.
Alcohol Res Health. 2011;34(1):76-85.
Despite the known damaging effects of prenatal alcohol exposure, women continue to drink during pregnancy, creating a need for effective interventions and treatments for fetal alcohol spectrum disorders (FASD). Experimental models can be useful in identifying potential treatments, and this article describes the spectrum of experimental therapeutics that currently are being investigated, including pharmacological, nutritional, and environmental/behavioral interventions. Some treatments target the underlying mechanisms that contribute to alcohol-induced damage, protecting against alcohol's teratogenic effects, whereas other treatments may enhance central nervous system plasticity either during alcohol exposure or long after alcohol exposure has ceased. The insights gained to date from experimental models offer several candidates for attenuating the deficits associated with FASD.
尽管已知孕期饮酒会产生有害影响，但仍有女性在孕期继续饮酒，这就需要对胎儿酒精谱系障碍（FASD）采取有效的干预措施和治疗方法。实验模型有助于识别潜在的治疗方法，本文介绍了目前正在研究的一系列实验性治疗方法，包括药理学、营养和环境/行为干预。一些治疗方法针对导致酒精性损伤的潜在机制，预防酒精的致畸作用，而其他治疗方法可能在酒精暴露期间或酒精暴露停止很久之后增强中枢神经系统的可塑性。迄今为止，从实验模型中获得的见解为减轻与FASD相关的缺陷提供了几个候选方法。
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