Department of Radiology, Westmead Hospital, Westmead, Australia; Discipline of Medical Radiation Sciences, Faculty of Health Sciences, University of Sydney, Sydney, Australia.
J Magn Reson Imaging. 2014 Jan;39(1):103-9. doi: 10.1002/jmri.24141. Epub 2013 Apr 11.
To directly compare the responsiveness of quantitative imaging measures of disease progression in knee osteoarthritis (OA). In the medial compartment of the knee comparison was made between: 1) radiographic joint space narrowing (JSN); 2) global quantitative magnetic resonance imaging (qMRI) of cartilage volume; 3) regional qMRI of cartilage thickness; and 4) regional analysis using an ordered value (OV) methodology.
3T MRI and weight-bearing radiography of the knees were performed at baseline and 1-year timepoints in 23 subjects (mean age 63 years) with symptomatic knee OA. Standardized response means (SRM) were calculated for each measure. Statistical analysis to determine significance of change between timepoints was performed with a two-tailed Student's t-test (JSN, global, regional analysis) and nonparametric Mann-Whitney test (ordered values).
At 1 year, global cartilage volume losses of 2.3% (SRM -0.44) in the medial tibia and 6.9% in the medial femur (SRM -0.74) were recorded. SRM for JSN was -0.46. Regional analysis revealed largest reductions in cartilage thickness in the external (SRM -0.84) weight-bearing subregion of the medial femur and in the posterior subregion of the medial tibia (SRM -0.79). OV analysis in the medial compartment revealed areas of cartilage thinning (four ranked OV) and cartilage thickening (two ranked OV).
The MRI OV approach proved to be a superior analysis tool for detecting changes in cartilage morphology over a 1-year period. Radiographically defined JSN was found to be the least responsive measurement method of knee OA disease progression.
直接比较膝关节骨关节炎（OA）疾病进展的定量影像学测量指标的反应性。在膝关节内侧间室中，对以下内容进行了比较：1）放射学关节间隙狭窄（JSN）；2）软骨容积的整体定量磁共振成像（qMRI）；3）软骨厚度的局部 qMRI；4）使用有序值（OV）方法进行的局部分析。
23 名有症状膝关节 OA 患者在基线和 1 年时进行了 3T MRI 和负重膝关节放射摄影。为每个测量值计算了标准化反应均值（SRM）。使用双侧学生 t 检验（JSN、整体、局部分析）和非参数曼-惠特尼检验（有序值）对确定时间点之间变化的显著性进行了统计分析。
在 1 年内，内侧胫骨的整体软骨容积损失了 2.3%（SRM-0.44），内侧股骨的损失了 6.9%（SRM-0.74）。JSN 的 SRM 为-0.46。局部分析显示，内侧股骨的外侧（SRM-0.84）和负重亚区以及内侧胫骨的后亚区的软骨厚度减少最大（SRM-0.79）。内侧间室的 OV 分析显示出软骨变薄（四个等级的 OV）和软骨增厚（两个等级的 OV）的区域。
MRI OV 方法被证明是一种优越的分析工具，可用于检测 1 年内软骨形态的变化。在影像学上定义的 JSN 是膝关节 OA 疾病进展最不敏感的测量方法。
