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沙特老年糖尿病患者急性冠状动脉综合征的管理

The management of elderly diabetic saudi patients with acute coronary syndrome.

作者信息

Kinsara Abdulhalim J, Hasanin Adel M

机构信息

Department of Cardiology, King Saud Bin Abdulaziz University for Health Sciences, King Abdul Aziz Medical City, Jeddah, Saudi Arabia.

出版信息

Heart Views. 2013 Jan;14(1):1-4. doi: 10.4103/1995-705X.107112.

Abstract

BACKGROUND AND PURPOSE

Elderly Diabetics (DM) who present with Acute Coronary Syndrome (ACS) constitute a very high risk group. We present the pattern of management of elderly patients (>65 years) in the Kingdom of Saudi Arabia (KSA) in comparison to the international data extrapolated from a Multicenter International Diabetes-Acute Coronary Syndromes (MIDAS).

MATERIALS AND METHODS

DM patients presenting with unstable angina or non-ST-segment elevation myocardial infarction (MI) at the time of admission to the hospital were collectively enrolled into the MIDAS study. A total of 3624 patients were enrolled; 142 were from Saudi Arabia. Primary clinical outcome measure was in-hospital death or MI. We present the data of KSA based on the age of the patients in comparison to the international registry.

RESULTS

Baseline characteristics were typical for DM presenting with ACS, with mean age of 67 ± 15 years, males, constituted 36% of patients while 94% of patients were DM type 2. There was marked underutilization of glycoprotein IIb/IIIa inhibitors in those aged over 65 years with a decrease from 22.5 to 12.7 in KSA (Odds ratio 0.56) patients. The percentage of early coronary angiography approach in KSA was less than that of the international data with further reduction of the percentage in Saudi elderly population (from 49.3% to 25.5% with Odds ratio 0.52).

CONCLUSIONS

In elderly Saudi diabetic patients admitted with ACS, there is tendency for underutilization of GP IIb/IIIa, early coronary angiography, and revascularization that needs to be addressed.

摘要

背景与目的

患有急性冠脉综合征(ACS)的老年糖尿病患者(DM)构成了一个极高危群体。我们展示了沙特阿拉伯王国(KSA)65岁以上老年患者的管理模式,并与从多中心国际糖尿病-急性冠脉综合征(MIDAS)推断出的国际数据进行比较。

材料与方法

入院时出现不稳定型心绞痛或非ST段抬高型心肌梗死(MI)的糖尿病患者被纳入MIDAS研究。共纳入3624例患者;其中142例来自沙特阿拉伯。主要临床结局指标是住院死亡或心肌梗死。我们根据患者年龄展示沙特阿拉伯的数据,并与国际注册数据进行比较。

结果

伴有急性冠脉综合征的糖尿病患者的基线特征具有典型性,平均年龄为67±15岁,男性占患者的36%,而94%的患者为2型糖尿病。65岁以上患者中糖蛋白IIb/IIIa抑制剂的使用明显不足,沙特阿拉伯患者(优势比0.56)的使用率从22.5%降至12.7%。沙特阿拉伯早期冠状动脉造影检查的比例低于国际数据,沙特老年人群中的这一比例进一步降低(从49.3%降至25.5%,优势比0.52)。

结论

在因急性冠脉综合征入院的沙特老年糖尿病患者中,存在糖蛋白IIb/IIIa、早期冠状动脉造影和血运重建使用不足的倾向,需要加以解决。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/741a/3621217/f0fa19d33634/HV-14-1-g002.jpg

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