Zdrazilova-Dubska L, Valik D, Budinska E, Frgala T, Bacikova L, Demlova R
Department of Laboratory Medicine, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
Klin Onkol. 2012;25 Suppl 2:2S21-5.
CD3+ CD56+ NKT-like cells have been shown to produce substantial amounts of pro-inflammatory cytokines and to mediate lysis of malignant cells. Using flow cytometry, we evaluated the absolute NKT-like cell count in peripheral blood from individuals in a reference population and the median number was 0.085 x 10(9)/l. The average number of NKT-like cells in patients with disseminated cancer was 2.65 fold higher than in the reference population. The number of CD3+ CD56+ cells in solid tumour patients who achieved complete remission was comparable to the reference population. In breast cancer patients with initially (prior to therapy) increased number of NKT-like cells, we observed a trend toward longer disease-free survival. Thus we conclude that CD3+ CD56+ NKT-like cells have potential to suppress tumour evasion and are expanded in peripheral blood of some epithelial tumour patients.
已证明CD3 + CD56 + NKT样细胞可产生大量促炎细胞因子并介导恶性细胞的裂解。我们使用流式细胞术评估了参考人群外周血中NKT样细胞的绝对计数，中位数为0.085×10⁹ /升。播散性癌症患者中NKT样细胞的平均数量比参考人群高2.65倍。实现完全缓解的实体瘤患者中CD3 + CD56 +细胞的数量与参考人群相当。在初始（治疗前）NKT样细胞数量增加的乳腺癌患者中，我们观察到无病生存期延长的趋势。因此，我们得出结论，CD3 + CD56 + NKT样细胞具有抑制肿瘤逃逸的潜力，并在一些上皮肿瘤患者的外周血中扩增。
