Department of Clinical Immunology, Medical University of Lublin, 20-093 Lublin, Poland.
Int J Mol Sci. 2021 Sep 1;22(17):9520. doi: 10.3390/ijms22179520.
NKT cells comprise three subsets-type I (invariant, iNKT), type II, and NKT-like cells, of which iNKT cells are the most studied subset. They are capable of rapid cytokine production after the initial stimulus, thus they may be important for polarisation of Th cells. Due to this, they may be an important cell subset in autoimmune diseases. In the current review, we are summarising results of NKT-oriented studies in major neurological autoimmune diseases-multiple sclerosis, myasthenia gravis, and Guillain-Barre syndrome and their corresponding animal models.
NKT 细胞包括三个亚群——I 型（不变的，iNKT）、II 型和 NKT 样细胞，其中 iNKT 细胞是研究最多的亚群。它们在最初的刺激后能够快速产生细胞因子，因此它们可能对 Th 细胞的极化很重要。因此，它们可能是自身免疫性疾病中的一个重要细胞亚群。在本综述中，我们总结了 NKT 定向研究在主要神经自身免疫性疾病——多发性硬化症、重症肌无力和格林-巴利综合征及其相应动物模型中的结果。
