Skin Cancer Institute, Dermatological Surgical Unit, Tauranga, New Zealand.
Australas J Dermatol. 2013 May;54(2):133-5. doi: 10.1111/j.1440-0960.2011.00861.x. Epub 2012 Feb 16.
Calciphylaxis is a rare life-threatening form of skin necrosis. Although traditionally observed in patients with end-stage renal disease and/or hyperparathyroidism, calciphylaxis has also been reported to occur in 'non-traditional' patients with normal renal and parathyroid function. We report a case of warfarin-induced calciphylaxis treated successfully with sodium thiosulphate and discuss the role of Vitamin K2 as a potential therapeutic option in the management of warfarin-induced calciphylaxis.
钙化防御是一种罕见的危及生命的皮肤坏死形式。虽然传统上观察到在终末期肾病和/或甲状旁腺功能亢进症患者中，但钙化防御也已在肾功能和甲状旁腺功能正常的“非传统”患者中报告。我们报告了一例华法林诱导的钙化防御，成功地用硫代硫酸钠治疗，并讨论了维生素 K2 在华法林诱导的钙化防御治疗中的潜在治疗选择的作用。
