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华法林诱导的钙化防御：病例报告及文献复习。

Warfarin-induced calciphylaxis: a case report and review of literature.

机构信息

Staten Island University Hospital, Staten Island, NY, USA.

出版信息

Int J Gen Med. 2013 Aug 9;6:665-9. doi: 10.2147/IJGM.S47397. eCollection 2013.

DOI:10.2147/IJGM.S47397
PMID:23966800
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3745288/
Abstract

Calciphylaxis is a challenging complication of end-stage renal disease, with an unknown underlying mechanism. Several risk factors have been identified, such as hyperphosphatemia, hypercalcemia, hyperparathyroidism, low serum albumin levels, and history of warfarin therapy. This article presents a case of calciphylaxis provoked by reintroduction of warfarin therapy, introducing the possibility of direct induction.

摘要

钙化防御是终末期肾病的一种具有挑战性的并发症，其潜在机制尚不清楚。已经确定了几个危险因素，如高磷血症、高钙血症、甲状旁腺功能亢进症、低血清白蛋白水平和华法林治疗史。本文介绍了一例因重新开始华法林治疗而引发的钙化防御病例，提出了直接诱导的可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/2061a2ac66c7/ijgm-6-665Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/1203beb17b34/ijgm-6-665Fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/93daeed80483/ijgm-6-665Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/0f11bc58ca1b/ijgm-6-665Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/2061a2ac66c7/ijgm-6-665Fig8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/1203beb17b34/ijgm-6-665Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/d8feb121834f/ijgm-6-665Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/050c531a9613/ijgm-6-665Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/e61e6d80ef67/ijgm-6-665Fig4.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/93daeed80483/ijgm-6-665Fig6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/0f11bc58ca1b/ijgm-6-665Fig7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e500/3745288/2061a2ac66c7/ijgm-6-665Fig8.jpg

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2
Warfarin-induced calciphylaxis in a chronic hypercalcemic patient.华法林诱发的慢性高钙血症患者的钙化防御
Indian J Dermatol Venereol Leprol. 2013 Jan-Feb;79(1):135. doi: 10.4103/0378-6323.104691.
3
Calciphylaxis in CKD and beyond.慢性肾脏病及其他疾病中的钙磷代谢异常相关性钙化
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Vitamin K-Dependent Protein Activation: Normal Gamma-Glutamyl Carboxylation and Disruption in Disease.维生素 K 依赖性蛋白激活：正常 γ-谷氨酰羧化和疾病中的破坏。
Int J Mol Sci. 2022 May 20;23(10):5759. doi: 10.3390/ijms23105759.
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