University of Oklahoma College of Medicine, Department of Surgery, Oklahoma City, OK 73104, USA.
J Pediatr Surg. 2013 Apr;48(4):796-800. doi: 10.1016/j.jpedsurg.2012.10.047.
The objective of this study was to identify factors associated with symptom relief in pediatric patients treated with laparoscopic cholecystectomy (LC) for biliary dyskinesia (BD).
This was a case-control study of pediatric patients diagnosed with BD between January 2004 and June 2011. Controls were patients with symptom resolution and cases were patients who did not experience symptom relief.
Fifty patients met study eligibility, of whom 43 were controls and 7 were cases. Mean follow-up for the cohort was 26.5months. Unadjusted comparisons suggested no significant differences (p>0.05) between the two groups in the distribution of demographic and clinical variables with the exception of preoperative duration of symptoms and presence of comorbidity. After adjusting for comorbidities, the only significant predictor associated with the resolution of symptoms after surgery was preoperative duration of symptoms (OR, 0.37; 95% CI, 0.15-0.94); 96% of patients with symptoms<12months had symptom relief versus 70% with symptoms≥12months.
Symptoms associated with BD can be successfully relieved with LC. These data suggest patients with preoperative symptoms for less than 12months are the most likely to have symptom relief after surgery.
本研究旨在确定与接受腹腔镜胆囊切除术（LC）治疗胆道运动障碍（BD）的儿科患者症状缓解相关的因素。
这是一项病例对照研究，纳入 2004 年 1 月至 2011 年 6 月期间诊断为 BD 的儿科患者。对照组为症状缓解患者，病例组为未出现症状缓解的患者。
50 例患者符合研究纳入标准，其中 43 例为对照组，7 例为病例组。该队列的平均随访时间为 26.5 个月。未经调整的比较表明，两组在人口统计学和临床变量的分布上没有显著差异（p＞0.05），但术前症状持续时间和并存疾病除外。在调整并存疾病后，与术后症状缓解相关的唯一显著预测因素是术前症状持续时间（OR，0.37；95%CI，0.15-0.94）；术前症状持续时间＜12 个月的患者中，96%有症状缓解，而术前症状持续时间≥12 个月的患者中，70%有症状缓解。
LC 可成功缓解 BD 相关症状。这些数据表明，术前症状持续时间＜12 个月的患者术后最有可能出现症状缓解。
