输卵管在卵巢癌起源中的作用。
The role of the fallopian tube in the origin of ovarian cancer.
机构信息
Division of Gynecologic Oncology, University of Alabama at Birmingham, Birmingham, AL.
出版信息
Am J Obstet Gynecol. 2013 Nov;209(5):409-14. doi: 10.1016/j.ajog.2013.04.019. Epub 2013 Apr 10.
Abstract
Advanced cases of epithelial ovarian, primary peritoneal, and primary tubal malignancies have a relatively poor prognosis and collectively remain the most deadly of all gynecologic malignancies. Although traditionally thought of as one disease process, ongoing research suggests that there is not 1 single site or cell type from which these cancers arise. A majority of the serous tumors appear to originate from dysplastic lesions in the distal fallopian tube. Therefore, what we have traditionally considered "ovarian" cancer may in fact be tubal in origin. In this article, we will review epithelial ovarian cancer classification and genetics, theories regarding cells of origin with a focus on tubal intraepithelial carcinoma, and implications for prevention and screening.
摘要
上皮性卵巢癌、原发性腹膜癌和原发性输卵管癌的晚期病例预后相对较差，它们共同构成所有妇科恶性肿瘤中最致命的类型。尽管传统上认为它们是一种疾病过程，但正在进行的研究表明，这些癌症并非源自单一部位或单一细胞类型。大多数浆液性肿瘤似乎起源于输卵管远端的发育不良病变。因此，我们传统上认为的“卵巢”癌实际上可能起源于输卵管。在本文中，我们将回顾上皮性卵巢癌的分类和遗传学，以及关于起源细胞的理论，重点是输卵管上皮内癌，并探讨其对预防和筛查的影响。
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