Department of ORL-HNS, College of Medicine, Dankook University, Cheonan, Republic of Korea.
Neurosci Lett. 2013 Jun 7;544:131-5. doi: 10.1016/j.neulet.2013.03.058. Epub 2013 Apr 11.
The aim of this study was to find out the effect of low-level laser therapy (LLLT) on salicylate-induced tinnitus in the rat model. Fourteen Sprague-Dawley rats (8 weeks; 240-280 gm) were divided into 2 groups (study group, control group). Rats of both groups were treated with 400 mg/kg/day of sodium salicylate for 8 consecutive days. Tinnitus was monitored using GPIAS (Gap Prepulse Inhibition of Acoustic Startle) 2 h after first salicylate treatment, and every 24 h during 9 days of treatment. Rats in laser group were irradiated to each ear with wavelength of 830 nm diode laser (165 mW/cm(2)) for 30 min daily for 8 days. During salicylate treatment, rats of study group irradiated with low level laser showed significantly higher GPIAS values throughout the experiment. Therapeutic effect of LLLT is demonstrated in animal tinnitus model by means of GPIAS. Further experimental studies are needed to find possible mechanisms and better methods to improve LLLT efficacy.
本研究旨在探讨低水平激光疗法（LLLT）对水杨酸盐诱导的大鼠耳鸣的影响。将 14 只 Sprague-Dawley 大鼠（8 周龄；240-280 克）分为 2 组（研究组、对照组）。两组大鼠均连续 8 天每天给予 400mg/kg 的水杨酸钠。在第一次水杨酸盐治疗后 2 小时，使用 GPIAS（Gap Prepulse Inhibition of Acoustic Startle）监测耳鸣，在治疗的 9 天中每 24 小时监测一次。激光组大鼠每天用波长为 830nm 的二极管激光（165mW/cm²）照射每只耳朵 30 分钟，共 8 天。在水杨酸盐治疗期间，研究组接受低水平激光照射的大鼠在整个实验过程中 GPIAS 值显著升高。GPIAS 证明了 LLLT 在动物耳鸣模型中的治疗效果。需要进一步的实验研究来寻找可能的机制和更好的方法来提高 LLLT 的疗效。
