Lyn 在 TIMP-1 红细胞生存信号通路中起着关键作用。
A crucial role for Lyn in TIMP-1 erythroid cell survival signalling pathway.
机构信息
Université de Reims Champagne Ardenne, CNRS FRE 3481 MEDyC, Laboratoire SiRMa, SFR CAP Santé, Moulin de la Housse, BP 1039, 51687 Reims, France.
出版信息
FEBS Lett. 2013 May 21;587(10):1524-8. doi: 10.1016/j.febslet.2013.03.032. Epub 2013 Apr 11.
TIMP-1, a well-known MMP inhibitor, displays other biological activities such as cell survival, proliferation and differentiation in hematopoietic cells. In this report, we investigated the role of the Src-related kinase Lyn in TIMP-1 induced UT-7 erythroleukemic cell survival. We showed that (i) tyrosine 507 of Lyn was dephosphorylated and Lyn kinase activity enhanced by TIMP-1, (ii) Lyn silencing suppressed TIMP-1 anti-apoptotic activity and (iii) Lyn was activated upstream the JAK2/PI 3-kinase/Akt pathway. Our data suggest a novel role for Lyn in erythroid cell survival.
TIMP-1，一种著名的 MMP 抑制剂，在造血细胞中表现出其他生物活性，如细胞存活、增殖和分化。在本报告中，我们研究了Src 相关激酶 Lyn 在 TIMP-1 诱导的 UT-7 红细胞白血病细胞存活中的作用。结果表明：（i）TIMP-1 使 Lyn 的酪氨酸 507 去磷酸化并增强 Lyn 激酶活性；（ii）Lyn 沉默抑制 TIMP-1 的抗凋亡活性；（iii）Lyn 在 JAK2/PI3-kinase/Akt 途径的上游被激活。我们的数据表明 Lyn 在红细胞存活中具有新的作用。
Zotero 插件