LRP-1：细胞外基质蛋白水解的一个检查点。
LRP-1: a checkpoint for the extracellular matrix proteolysis.
机构信息
CNRS FRE 3481 MEDyC (Matrice Extracellulaire et Dynamique Cellulaire), Laboratoire SiRMa (Signalisation et Récepteurs Matriciels), Université de Reims Champagne-Ardenne (URCA), Reims, France.
出版信息
Biomed Res Int. 2013;2013:152163. doi: 10.1155/2013/152163. Epub 2013 Jul 10.
Abstract
Low-density lipoprotein receptor-related protein-(LRP-1) is a large endocytic receptor that binds more than 35 ligands and exhibits signaling properties. Proteinases capable of degrading extracellular matrix (ECM), called matrix proteinases in this paper, are mainly serine proteinases: the activators of plasminogen into plasmin, tissue-type (tPA) and urokinase-type (uPA) plasminogen activators, and the members of the matrix metalloproteinase (MMP) family. LRP-1 is responsible for clearing matrix proteinases, complexed or not with inhibitors. This paper attempts to summarize some aspects on the cellular and molecular bases of endocytic and signaling functions of LRP-1 that modulate extra- and pericellular levels of matrix proteinases.
摘要
载脂蛋白相关蛋白 1（LRP-1）是一种大型内吞受体，可结合 35 多种配体并表现出信号特性。本文将能够降解细胞外基质（ECM）的蛋白酶称为基质蛋白酶，它们主要是丝氨酸蛋白酶：纤溶酶原转化为纤溶酶的激活剂，组织型（tPA）和尿激酶型（uPA）纤溶酶原激活剂，以及基质金属蛋白酶（MMP）家族的成员。LRP-1 负责清除与抑制剂结合或不结合的基质蛋白酶。本文试图总结 LRP-1 的内吞和信号功能的细胞和分子基础的某些方面，这些功能调节细胞外和细胞周基质蛋白酶的水平。
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